نتایج جستجو برای: anti influenza agents
تعداد نتایج: 738542 فیلتر نتایج به سال:
Abstract Several influenza pandemics have impacted our life, each with variable prevalence and severity. In a search for natural antivirals, further phytochemical investigation of Gardenia latifolia Aiton, Rubiaceae, was conducted. As result, five structurally diverse glycosides were isolated, offering valuable chemotaxonomic data. Using the crystal violet technique, three isolates, canthoside ...
Herbs have been used as a form of traditional medicine since ancient times. Licorice is one the herbs that has long medicine. This plant contains different compounds, such glycyrrhizin, 18??glycyrrhetinic acid, glabrins A and B, isoflavones, showing various pharmacological activities. Pharmacological experiments shown extracts pure compounds this species exhibit broad biological properties, inc...
The RNA-dependent RNA polymerase of influenza A virus comprises conserved and independently-folded subdomains with defined functionalities. The N-terminal domain of the PA subunit (PA(N)) harbors the endonuclease function so that it can serve as a desired target for drug discovery. To identify a class of anti-influenza inhibitors that impedes PA(N) endonuclease activity, a screening approach th...
There are many effective chemotherapeutic agents used in influenza disease which some of them inhibit virus replication by interfering with FluV (influenza virus) viral binding or its penetration into cell membrane. A series of polyoxometalates compounds such as POM-523 and PM-504 have been synthesized and have showed inhibitory effects on viruses. In this study we examined anti influenza activ...
Oxidative stress was found to have a role in many viral diseases including AIDS, hepatitis and influenza. In the present study the pathology of influenza viral infection in the lungs, which may lead to oxidative stress, was investigated and an attempt was made to study the efficacy of anti-oxidants as therapeutic agents. Adult male mice of Swiss albino type were infected with influenza virus (A...
By using a cell-based high throughput screening campaign, a novel angelicin derivative 6a was identified to inhibit influenza A (H1N1) virus induced cytopathic effect in Madin-Darby canine kidney cell culture in low micromolar range. Detailed structure-activity relationship studies of 6a revealed that the angelicin scaffold is essential for activity in pharmacophore B, while meta-substituted ph...
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