one patient with tricuspid incompetence due to a ruptured papillary muscle after myocardial infarction. The higher incidence of left ventricular papillary muscle dysfunction reported (Heikkila, 1967) must be largely due to the higher incidence of left ventricular infarction observed by various workers (Wartman & Hellerstein, 1948; Zaus & Kearns, 1952). This patient had minimal dilatation of the...

The digoxin content was measured in samples of left ventricular papillary muscle, skeletal muscle, and plasma obtained during mitral valve replacement from eight patients on maintenance treatment with the drug. The content in papillary muscle ranged from 15-5 to 132 ng/g (mean 77-7) and in skeletal muscle from 7-5 to 23 ng/g (mean 11-3). The ratio of myocardial digoxin concentration to plasma c...

RUPTURE of a papillary muscle is a rare complication of myocardial infarction.1 2 The combination of coronary artery disease with severe mitral regurgitation usually results in a rapid, deteriorating course. Not until 1948 was this diagnosis correctly made ante mortem.3 Sanders et al., in 1957, discussed 61 cases of rupture of a papillary muscle and pointed out the important clinical features o...

To determine whether canine epicardium and endocardium show intrinsically different electrophysiological responses to metabolic alterations that occur during acute myocardial ischemia in vivo, endocardial, epicardial, papillary muscle tip, and Purkinje fibers (PF) were superfused in vitro with Tyrode's solution containing 8.0 DM KC1 at a pH of 6.85 and a Po2 < 50 mm Hg. During the initial 10 mi...

HOFFMAN, BRIAN F. AND JOHN J. KELLY, JR. Efects of rate and rhythm on contraction of rat papillary musch~. Am. J. Ph ysiol. Ig7(6): 1 Igg-1204. 1959. -The unusual relationship between frequency of contraction and tension developed by the isolated rat papillary muscle has been studied in detail. The progressive decrease in tension with increasing rate is unrelated to the size or weight of the mu...

Technological advances during the past decade have significantly enhanced our ability to successfully map and ablate ventricular arrhythmias in patients with a structurally normal heart, as well as various forms of underlying cardiac disease. Increased recognition of the deleterious effects of ventricular arrhythmias, such as the potential of frequent premature ventricular complexes (PVCs) to i...