Hyperacidity in the stomach is known to promote the progression of gastric cancer. The plant-derived chemotherapeutic curcumin is used to treat gastric cancer. The objective of this study was to investigate whether curcumin regulates gastrin-mediated acid secretion in suppressing gastric cancer. Gastric cancer cells were treated with 25 μm curcumin, followed by Annexin V/propidium iodide double...

BACKGROUND HIV-induced CD4(+) and CD8(+) T-cell apoptosis decreases upon start of combination antiretroviral therapy (cART). Although in vitro evidence suggests an anti-apoptotic effect of protease inhibitors (PIs) as opposed to non-nucleoside reverse transcriptase inhibitors (NNRTIs), in vivo studies are inconclusive about effects of differential cART regimens on T-cell apoptosis. METHODS Pe...

Acute myeloid leukemia (AML) is a complex hematological disorder characterized by blockage of differentiation and high proliferation rates progenitors. Anthracycline cytarabine‑based therapy has remained the standard treatment for AML over last four decades. Although this strategy increased survival rates, patients often develop resistance to these drugs. Despite efforts understand mechanisms u...

Abstract Background Parkinson’s disease (PD) is the second most common neurodegenerative after Alzheimer's disease. The oxidative stress an important component of pathogenesis PD. Artemisinin (ART) has antioxidant and neuroprotective effects. purpose this study to explore effect ART on 1-methyl-4-phenyliodine iodide (MPP + )-treated SH-SY5Y cells underlying mechanism. Methods We used MPP -treat...

BACKGROUND Histone deacetylase (HDAC) inhibitors are emerging as a new class of anti-cancer drugs that promote cancer cell apoptosis, and include suberoylanilide hydroxamic acid (SAHA). The aim of this study was to investigate the mechanism of SAHA-induced apoptosis in human prostate cancer cell lines, DU145 and PC-3. MATERIAL AND METHODS Cell lines, DU145 and PC-3, were studied before and afte...

Introduction/Theory: Molecular imaging is emerging as a potential tool for monitoring treatment response in the management of cancer patients. Recent cell biology as well as oncology research has focused on investigating apoptosis or programmed cell death as a means of measuring these induced effects and detecting response. A hallmark of early stage apoptosis is the externalization of phosphati...

Atherosclerosis and coronary heart disease are causing high morbidity and mortality worldwide. Different risk factors have been demonstrated, but the exact mechanisms behind these diseases are still not fully understood. Recent studies have suggested Chlamydia pneumoniae to be involved in the pathogenesis, and increased apoptotic indexes in atherosclerotic plaques have been documented. In this ...

introduction: apoptosis is a major consequence of ionizing radiation in proliferative tissues and quantification of the apoptotic cells could be helpful for noninvasive assessment and estimation of the radiation absorbed dose. annexin v conjugated with super paramagnetic iron oxide nanoparticles (anx-spio) is a biological probe for detection of apoptotic cells using magnetic resonance imaging. ...

OBJECTIVE Withaferin A, a natural withanolide, has shown anti-cancer properties in various cancers including breast cancer, but its effects in ovarian cancer remain unexplored. Notch 1 and Notch3 are critically involved in ovarian cancer progression. We decided to examine the effects of Withaferin A in ovarian carcinoma cell lines and its molecular mechanism of action including its regulation o...

Hepatocellular carcinoma or hepatoma is a primary malignant neoplasm that responsible for 75–90% of all liver cancer in humans. Nanotechnology introduced the dual drug nanodelivery method as one initiatives nanomedicine therapy. Graphene oxide (GO) loaded with protocatechuic acid (PCA) and chlorogenic (CA) have shown some anticancer activities both passive active targeting. The physicochemical ...