1. In view of the large number of possible molecular targets of general anaesthetics, it is necessary to have some criteria for judging which targets are important for producing general anaesthesia and which are probably not. 2. We consider in detail two criteria: sensitivity to clinically relevant concentrations of anaesthetics and stereoselectivity to anaesthetic optical isomers. 3. The targe...

Halothane and enflurane were compared in 131 children undergoing adenoidectomy with or without tonsillectomy. Anaesthesia for adenoidectomy was induced with thiopentone or Althesin and for tonsillectomy with thiopentone. The response to surgery was minimal (0-5%) during both inhalation anaesthetics. During immediate recovery, respiratory depression was more profound after enflurane than after h...

This book gives a full account of the substances and devices adopted to make labour painless. There is a full discussion about the merits and demerits of the various drugs used. There is a discourse about the special attention to be given to expecting mothers to prepare them for the co-operation on their part?which according to the authors goes a long way for the success of the use of analgesic...

Serotonergic neurotransmission is involved in controlling arousal levels in humans and other animals. Here, the effects of serotonergic receptor antagonists on the induction and depth of anaesthesia produced by three different general anaesthetics were investigated. Rats were pretreated (i.p.) with either methiothepin (1.5 mg kg(-1)), mianserin (5 mg kg(-1)), ketanserin (7 mg kg(-1)) or saline....

Part 2 of this paper deals with the techniques for drug delivery of topical and injectable local anaesthetics. The various routes of local anaesthetic delivery (epidural, peripheral, wound catheters, intra-nasal, intra-vesical, intra-articular, intra-osseous) are explored. To enhance transdermal local anaesthetic permeation, additional methods to the use of an eutectic mixture of local anaesthe...

Pain is still an actual problem in dentistry, and a usage of anaesthetics can be still limited, so new ways of caries treatment are still being searched in order to ease this process both to a patient and a doctor. Efficiency of chemomechanical tooth treatment to children was studied. 30 children within two age groups of 3-6 and 7-13 years took part in this research, and their teeth with caries...

Editor, To achieve extended anaesthesia and analgesia, a psoas compartment–sciatic nerve block (PCSNB) requires administration of large volumes of potentially cardiotoxic local anaesthetics. Due to the anatomic location of the lumbar plexus [1], mostly within muscle tissue, initial absorption of the administered local anaesthetics after a psoas compartment block could result in relatively high ...

We have investigated the effect of volatile anaesthetics on protein synthesis and secretion in Hartley male guinea pig liver slices. The slices (250-300 microns thick) were incubated in sealed roller vials containing Krebs-Henseleit buffer at 37 degrees C under 95% oxygen. Volatile anaesthetics were vaporized in the vials to produce constant concentrations in the medium. Halothane 1-2.1 mmol li...