نتایج جستجو برای: als

تعداد نتایج: 27090  

2017
Barış Genç Javier H. Jara Amiko K. B. Lagrimas Peter Pytel Raymond P. Roos M. Marsel Mesulam Changiz Geula Eileen H. Bigio P. Hande Özdinler

Apical dendrites of Betz cells are important sites for the integration of cortical input, however their health has not been fully assessed in ALS patients. We investigated the primary motor cortices isolated from post-mortem normal control subjects, patients with familial ALS (fALS), sporadic ALS (sALS), ALS with frontotemporal dementia (FTD-ALS), and Alzheimer's disease (AD), and found profoun...

2016
Sabrina K. Hollinger Ike S. Okosun Cassie S. Mitchell

Multiple studies have shown that antecedent diseases are less prevalent in amyotrophic lateral sclerosis (ALS) patients than the general age-matched population, which suggests possible neuroprotection. Antecedent disease could be protective against ALS or, conversely, the asymptomatic early physiological underpinnings of ALS could be protective against other antecedent disease. Elucidating the ...

Journal: :MMWR supplements 2014
Paul Mehta Vinicius Antao Wendy Kaye Marchelle Sanchez David Williamson Leah Bryan Oleg Muravov Kevin Horton

PROBLEM/CONDITION Amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig's disease, is a progressive and fatal neuromuscular disease for which no cure has been identified. Although ALS has no known definitive cause, familial ALS (a hereditary form) occurs in 5%-10% of cases. Many hypotheses have been formulated about what causes ALS, including chemical exposures, occupational exposur...

Journal: :Molecular endocrinology 1998
G T Ooi K R Hurst M N Poy M M Rechler Y R Boisclair

After birth, the endocrine actions of insulin-like growth factor (IGF)-I and -II become increasingly important. In postnatal animals, most of circulating IGFs occur in 150-kDa complexes formed by association of an acid-labile subunit (ALS) with complexes of IGF and IGF-binding protein-3. ALS is synthesized almost exclusively in liver. GH stimulates the transcription of the ALS gene, resulting i...

Journal: :Archives of neurology 2006
Gregory A Rippon Nikolaos Scarmeas Paul H Gordon Peregrine L Murphy Steven M Albert Hiroshi Mitsumoto Karen Marder Lewis P Rowland Yaakov Stern

BACKGROUND Cognitive impairment is increasingly recognized in patients with amyotrophic lateral sclerosis (ALS). Clinical and pathologic features overlap in frontotemporal lobar dementia and ALS. Demographics, respiratory status, bulbar site of onset, and disease severity are potential risk factors for cognitive impairment in ALS. OBJECTIVES To further delineate the frequency, nature, and imp...

Journal: :Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2011
Patricia Lillo Eneida Mioshi Margaret C Zoing Matthew C Kiernan John R Hodges

Our objectives were to assess the frequency of behavioural changes in patients with amyotrophic lateral sclerosis (ALS) and to compare the clinical profile of ALS patients with those with behavioural variant frontotemporal dementia (bvFTD). Ninety-two patients with ALS and their carers participated in a postal survey. ALS patients completed self-report measures of motor function and mood. Eight...

Journal: :Archives of neurology 2011
Hussein Daoud Véronique Belzil Sandra Martins Mike Sabbagh Pierre Provencher Lucette Lacomblez Vincent Meininger William Camu Nicolas Dupré Patrick A Dion Guy A Rouleau

OBJECTIVE To analyze the ataxin 2 (ATXN2) CAG repeat size in a cohort of patients with amyotrophic lateral sclerosis (ALS) and healthy controls. Large (CAG)(n) alleles of the ATXN2 gene (27-33 repeats) were recently reported to be associated with an increased risk of ALS. DESIGN Case-control study. SETTING France and Quebec, Canada. PARTICIPANTS A total of 556 case patients with ALS and 4...

2013
Yu-Wei Lin Ming-Liang Lai

Introduction Uric acid (UA) may act as an antioxidant in ALS pathophysiology. This study examined whether serum UA concentration correlates to clinical course in the ALS patients. Methods We measured serum UA levels in 51 sporadic ALS patients, and compared them to 51 age-and-gender-matched healthy subjects. We analyzed the correlation between serum UA levels, illness duration , and disease “co...

2016
Bert Tuk Alan Gill Pieter Gaillard

Based upon a review of published clinical observations regarding syphilitic amyotrophic lateral sclerosis (ALS), I hypothesize that syphilis is actually a confounding factor, not a causative factor, in syphilitic ALS. Moreover, I propose that the successful treatment of ALS symptoms in patients with syphilitic ALS using penicillin G and hydrocortisone is an indirect consequence of the treatment...

2016
Stavroula Tsitkanou Paul A. Della Gatta Aaron P. Russell

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a fatal motor neuron disorder. It results in progressive degeneration and death of upper and lower motor neurons, protein aggregation, severe muscle atrophy and respiratory insufficiency. Median survival with ALS is between 2 and 5 years from the onset of symptoms. ALS manifests as either familial ALS (FALS) (~10%...

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