Aflatoxins (AFs) are one of the most important mycotoxins due to their common occurrence in feedstuffs and feeds that pose a serious threat to humans and animals. Although many outbreaks of acute and chronic diseases have been attributed to consumption of aflatoxin-contaminated foods, the most significant effect of aflatoxin is hepatotoxicity in farm animals, especially aflatoxicosis in shrimps...

dried figs collected from various exporting companies (2,461 samples) and local stores (219 samples) were analyzed using reverse-phase high-performance liquid chromatography (rp-hplc) to determine and compare the incidence of aflatoxins, the effectiveness of the regulation limits and monitoring system to select non-compliant samples and the mean daily aflatoxin exposures. the incidence rates of...

Among the over 185 known species within the genus Aspergillus, Aspergillus flavus is the most economically important because it produces the toxic and carcinogenic aflatoxins. Its non-aflatoxigenic relative A. oryzae is used extensively for food fermentations (Jelinek et al., 1989). It is one of the most abundant soil-borne molds on earth. A. flavus fungus is a saprobe mold that is capable of s...

ince the mechanical picker-sheller has come into widespread use for harvesting field corn, farmers generally are confronted with the problem of safe storage of highmoisture shelled corn. The moisture content of field-shelled corn is often too high for direct binning, and storing such grain in regular farm bins without first lowering the moisture level is almost certain to result in spoilage. Mo...

The effects of a number of carcinogens and hepatotoxins on the binding kinetics of the interactions of glucocorticoidcytosol receptor complex with nuclear acceptor sites in rat liver were investigated. Both the apparent sites in rat liver were investigated. Both the apparent concentration of nuclear binding sites and the Kd were significantly diminished following treatment of rats with subletha...

The purpose of this study was to evaluate the effects of corn naturally contaminated with aflatoxin B1 and aflatoxin B2 on pathological lesions, apoptosis, cell cycle phases and T lymphocyte subsets of spleen, and to provide an experimental basis for understanding the mechanism of aflatoxin-induced immunosuppression. A total of 900 COBB500 male broilers were randomly allocated into five groups ...

Azadbakht N1, Khosravinegad K2, Tarrahi MJ3 1. MSc in plant pathology, Khorramabad, Iran 2. BSc in livestock sciences, Khorramabad, Iran 3. Instrustor, Department of Epidemiology, Faculty of Health, Lorestan University of Medical Sciences , Khorramabad, Iran Abstract Background: Aflatoxins belong to a group of toxins called mycotoxins that infection with them can cause complications in humans...

In the 1960s, 100 000 turkeys were lost in the UK as a consequence of an intoxication due to toxic metabolite coming from fungi. The cause of this disease was traced to a feed component, peanut meal which was infested by Aspergillus flavus, fungi that commonly grows in this substrate during its storage. Aflatoxins are considered to be one of the most dangerous contaminants in food and feeds. Af...

Aflatoxins are food-borne secondary toxic fungal metabolites produced during the growth of Aspergillus flavus and A. parasiticus. Aflatoxins are well known hepatotoxic, hepatocarcinogenic and mutagenic agents. These effects are mainly due to adduct formation with DNA, RNA and protein. In addition, it also causes lipid peroxidation as well as oxidative damage to DNA. AFB1 possess genotoxic poten...