Long-term exposure to social and biological/physical stressful events produces stress responses. The hypothalamic-pituitary-adrenal (HPA) axis is one of the main neuroendocrine regulatory systems in process stress. Recent studies have shown that skin, as a large endocrine organ, also has peripheral functions similar central HPA axis. skin responds positively range symptoms. This review will int...

Objective(s) The mechanism(s) by which antidepressants regulate the hypothalamic-pituitary-adrenal (HPA) axis remain elusive. The endocannabinoid system (eCBs) which exhibits antidepressant potential, appears to regulate the HPA axis activity. Therefore, we aimed to investigate the role of the eCBs in the action of doxepin including its effect on the HPA axis. Materials and Methods Male Wist...