Tissue-resident memory T (TRM) cells have been widely characterized in infectious disease settings; however, their role in mediating immunity to cancer remains unknown. We report that skin-resident memory T cell responses to melanoma are generated naturally as a result of autoimmune vitiligo. Melanoma antigen-specific TRM cells resided predominantly in melanocyte-depleted hair follicles and wer...

At 5 degree C addition of CO2 or HCO3- to CO (HCO3-)-depleted thylakoids (containing 100 mM formate) initiates, within 10 s, the activation of the Hill reaction in light. In contrast to HCO3- addition, where there is a lag of 6-8 s, the activation by CO2 addition is almost instantaneous. With CO2, prior addition of carbonic anhydrase produces a lag of about 6 s that approaches the lag observed ...

We provide a new sequential predictors approach for the exponential stabilization of linear time-varying systems. Our method circumvents the problem of constructing and estimating distributed terms in the control laws, and allows arbitrarily large input delay bounds, pointwise time-varying input delays, and uncertainties. Instead of using distributed terms, our approach to handling longer delay...

In this paper, we describe a stabilization method for linear time-delay systems which extends the classical pole placement method for ordinary di7erential equations. Unlike methods based on :nite spectrum assignment, our method does not render the closed loop system, :nite dimensional but consists of controlling the rightmost eigenvalues. Because these are moved to the left half plane in a (qua...

We discuss a nite horizon H∞ control problem for time-varying systems with input delays. Clarifying a relationship between two H∞ control problems in input delay case and in measurement delay case, we derive a solution in input delay case based on the known result for the H∞ control problem in measurement delay case, and show that the solution has the same predictor–observer structure as the so...