CRP was first described in 1927 by Gougerot and Carteaud and it occurs predominantly in young adults and teenagers, affecting the neck, upper trunk and axillae with cosmetically displeasing appearance. Recognition of CRP is usually difficult by clinicians, including dermatologist as it frequently appears as pityriasis versicolor or acanthosis nigricans resulting in delay in the diagnosis [2]. H...

Acanthosis nigricans (AN) is a skin disorder characterized by focal or diffuse hyperkeratosis symmetric hyperpigmentation of the skin and oral cavity mucosa. Various neoplasms, especially gastrointestinal adenocarcinomas are associated with acanthosis nigricans (AN malignant). Chemotherapy may cause regression of skin lesions. The etiology of AN is not clear. A role of growth factors such as me...

A 55-year-old man presented with oral mucosal ulcers, blackening of both hands, and hyperpigmentation on axillary, anal, and inguinal regions for the last 3 months, which were all progressive. The patient was referred to the oncology department with the diagnosis of acanthosis nigricans for investigation of an underlying malignancy. He was a smoker. A computed tomography scan of thorax revealed...

Sir, Naevoid acanthosis nigricans (AN) is an extremely rare form of AN that can manifest with a characteristic naevoid appearance at any age before puberty (1 – 3). It is not associated with any known syndrome, endocrinopathy, drugs or internal malignancy (1 – 3) and, thus far, there have been only 2 case reports in the literature of naevoid AN with a unilateral distribution (1, 2). We report a...

Tripe palms, which described the thickening of pamar skin with increase of normal dermatoglyphics and a peculiar velvety texture, is a specific cutaneous paraneoplastic syndrome especially related to cancers of upper aerodigestive tract. Acanthosis nigricans, and florid cutaneous papillomatosis (sudden appearance of many warty skin lesions) are the most commonly associated paraneoplastic dermat...

218 Ann Dermatol Received December 27, 2010, Revised January 11, 2011, Accepted for publication January 11, 2011 Corresponding author: David R. Berk, M.D., Campus Box 8123, 4921 Parkview Place, St. Louis, MO 63110, USA. Tel: 1-314-747-3679, Fax: 1-314-747-8693, E-mail: [email protected] This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Comm...