نتایج جستجو برای: abcg1 abcg5 pyy 3

تعداد نتایج: 1812486  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Nan Wang Debin Lan Wengen Chen Fumihiko Matsuura Alan R Tall

The mechanisms responsible for the inverse relationship between plasma high-density lipoprotein (HDL) levels and atherosclerotic cardiovascular disease are poorly understood. The ATP-binding cassette transporter A1 (ABCA1) mediates efflux of cellular cholesterol to lipid-poor apolipoproteins but not to HDL particles that constitute the bulk of plasma HDL. We show that two ABC transporters of un...

Journal: :Bioscience, biotechnology, and biochemistry 2009
Tadateru Hamada Yoko Kodama Hitomi Goto Takeshi Yoshida Katsumi Imaizumi Ikuo Ikeda

Stroke-prone spontaneously hypertensive rats (SHRSP) deposit plant sterols in their bodies and have a mutation in ATP binding cassette transporter G5 (Abcg5). Lymphatic recovery rates of campesterol and sitosterol in SHRSP rats were comparable to those in Wistar rats, a strain that does not deposit plant sterols in the body and has no mutation in Abcg5. Higher absorption of stigmasterol and sit...

Journal: :The Journal of clinical investigation 2008
Naoki Terasaka Shuiqing Yu Laurent Yvan-Charvet Nan Wang Nino Mzhavia Read Langlois Tamara Pagler Rong Li Carrie L Welch Ira J Goldberg Alan R Tall

Plasma HDL levels are inversely related to the incidence of atherosclerotic disease. Some of the atheroprotective effects of HDL are likely mediated via preservation of EC function. Whether the beneficial effects of HDL on ECs depend on its involvement in cholesterol efflux via the ATP-binding cassette transporters ABCA1 and ABCG1, which promote efflux of cholesterol and oxysterols from macroph...

2013
Zhi-Yong Fan Zhong-Hua Liu

The aim of this study was to determine the effects of immunization against Peptide tyrosine tyrosine (PYY) on the growth performance and endocrine hormone levels in the blood serum of rats. Sixty Sprague-Dawley rats were randomly assigned to four treatment groups, with five replicates in each group and three rats for each replicate. The antiserum of PYY was injected into the rats thrice every 8...

Journal: :The Journal of clinical investigation 2010
Jeffrey M Sturek J David Castle Anthony P Trace Laura C Page Anna M Castle Carmella Evans-Molina John S Parks Raghavendra G Mirmira Catherine C Hedrick

Cholesterol is a critical component of cell membranes, and cellular cholesterol levels and distribution are tightly regulated in mammals. Recent evidence has revealed a critical role for pancreatic beta cell-specific cholesterol homeostasis in insulin secretion as well as in beta cell dysfunction in diabetes and the metabolic response to thiazolidinediones (TZDs), which are antidiabetic drugs. ...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2006
Mollie Ranalletta Nan Wang Seongah Han Laurent Yvan-Charvet Carrie Welch Alan R Tall

OBJECTIVE Recent studies indicate that the ATP-binding cassette transporter ABCG1 can promote cholesterol efflux from macrophages to high-density lipoprotein. This study was designed to assess the in vivo role of macrophage ABCG1 in atherosclerosis. METHODS AND RESULTS Bone marrow from Abcg1-/- mice was transplanted into irradiated Ldlr-/- recipients, and atherosclerosis was evaluated by aort...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2007
Lukas Degen Juergen Drewe Franziska Piccoli Karin Gräni Sibylle Oesch Raluca Bunea Massimo D'Amato Christoph Beglinger

Cholecystokinin (CCK), peptide YY (PYY), and ghrelin have been proposed to act as satiety hormones. CCK and PYY are stimulated during meal intake by the presence of nutrients in the small intestine, especially fat, whereas ghrelin is inhibited by eating. The sequence of events (fat intake followed by fat hydrolysis and CCK release) suggests that this process is crucial for triggering the effect...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2011
Joan Carles Escolà-Gil Gemma Llaverias Josep Julve Matti Jauhiainen Jesús Méndez-González Francisco Blanco-Vaca

OBJECTIVE A high-saturated fatty acid- and cholesterol-containing (HFHC) diet is considered to be a major risk factor for cardiovascular disease. The present study aimed to determine the effects of this Western-type diet on high-density lipoprotein (HDL) metabolism and reverse cholesterol transport (RCT) from macrophages to feces. METHODS AND RESULTS Experiments were carried out in mice fed a...

2011
Tim Vanmierlo Kris Rutten Leonie C. van Vark - van der Zee Silvia Friedrichs Vincent W. Bloks Arjan Blokland Frans C. Ramaekers Eric Sijbrands Harry Steinbusch Jos Prickaerts Folkert Kuipers Dieter Lütjohann Monique Mulder

Plant sterols such as sitosterol and campesterol are frequently applied as functional food in the prevention of atherosclerosis. Recently, it became clear that plasma derived plant sterols accumulate in murine brains. We questioned whether plant sterols in the brain are associated with alterations in brain cholesterol homeostasis and subsequently with brain functions. ATP binding cassette (Abc)...

2012
XiaFang Chen Xueliang Du JianXing Zhu LiJuan Xie YongJun Zhang ZhenJuan He

The objective was to elucidate the relationships between serum concentrations of the gut hormone peptide YY (PYY) and ghrelin and growth development in infants for potential application to the clinical observation index. Serum concentrations of PYY and ghrelin were measured using radioimmunoassay from samples collected at the clinic. For each patient, gestational age, birth weight, time require...

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