نتایج جستجو برای: 5fluorouracil
تعداد نتایج: 94 فیلتر نتایج به سال:
In this issue of the Journal, Labianca et al. (1) report the results of a randomized trial comparing intraportal chemotherapy, systemic chemotherapy, or the combination of both regimens as adjuvant therapy for patients with Dukes’ stage B or C colon carcinoma. 5-Fluorouracil at a dosage of 500 mg/m of body surface area with 5000 IU of heparin was given through the portal vein for 7 days, starti...
The dawn of the modern era of randomized drug treatment trials (RCTs) in clinical medicine was ushered in by the seminal study of streptomycin versus placebo for the treatment of tuberculous meningitis reported in 1948 [1]. As drugs with apparent promise for treating cancer in humans emerged from cell culture and animal studies, the oncology community experimented with and subsequently embraced...
Purpose: Breast cancer stem cells have been shown to be associated with resistance to chemotherapy in vitro, but their clinical significance remains to be clarified. The aim of this study was to investigate whether cancer stem cells were clinically significant for resistance to chemotherapy in human breast cancers. Experimental Design: Primary breast cancer patients (n = 108) treated with neoad...
Using 50 percent growth inhibition of Physarum polycephalum (a coenocytic slime mold) as a screen for the selection of antitumor agents, 44 of the 195 compounds tested were effective at concentrations of@lOO @tg/m1. Results of inhibition of KB cell cul ture screen are given for comparison. INTRODUCTION Physanun polycephalum can be grown in a surface culture as a large, multinucleate plasmodium ...
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