نتایج جستجو برای: 450 inhibition

تعداد نتایج: 351106  

Journal: :Antimicrobial agents and chemotherapy 1999
D C Lamb S Maspahy D E Kelly N J Manning A Geber J E Bennett S L Kelly

Sterol delta22-desaturase has been purified from a strain of Candida glabrata with a disruption in the gene encoding sterol 14alpha-demethylase (cytochrome P-45051; CYP51). The purified cytochrome P-450 exhibited sterol delta22-desaturase activity in a reconstituted system with NADPH-cytochrome P-450 reductase in dilaurylphosphatidylcholine, with the enzyme kinetic studies revealing a Km for er...

2002
R. JEFCOATE WILLIAM H. ORME - JOHNSON

Steroid-induced difference spectra have been used to examine the combination of cholesterol with adrenal mitochondrial cytochrome P-450 which participates in cholesterol side chain cleavage (P-450,,,) and the depletion of cholesterol from the cytochrome which results from turnover of the enzyme system. Type I difference spectra induced by cholest5-ene-3fi,25-diol (25-hydroxycholesterol) and cho...

Journal: :Organic & biomolecular chemistry 2013
Jaime Garcia-Hartjes Silvia Bernardi Carel A G M Weijers Tom Wennekes Michel Gilbert Francesco Sansone Alessandro Casnati Han Zuilhof

Cholera toxin (CT), the causative agent of cholera, displays a pentavalent binding domain that targets the oligosaccharide of ganglioside GM1 (GM1os) on the periphery of human abdominal epithelial cells. Here, we report the first GM1os-based CT inhibitor that matches the valency of the CT binding domain (CTB). This pentavalent inhibitor contains five GM1os moieties linked to a calix[5]arene sca...

Journal: :Neuropsychologia 2006
Mariana Schmajuk Mario Liotti Laura Busse Marty G Woldorff

In a recent ERP study of inhibitory control using the Stop-Signal Task [Pliszka, S., Liotti, M., Woldorff, M. (2000). Inhibitory control in children with attention-deficit/hyperactivity disorder: Event-related potentials identify the processing component and timing of an impaired right-frontal response-inhibition mechanism. Biological Psychiatry, 48, 238-246], we showed that in normal children ...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2000
B Ma T Prueksaritanont J H Lin

The inhibitory effects of six commonly used calcium channel blockers on three major cytochrome P-450 activities were examined and characterized in human liver microsomes. All six compounds reversibly inhibited CYP2D6 (bufuralol 1'-hydroxylation) and CYP2C9 (tolbutamide methyl hydroxylation) activities. The IC(50) values for the inhibition of CYP2D6 and CYP2C9 for nicardipine were 3 to 9 microM,...

2009
Michele Schiariti Angela Saladini Attilio Placanica Marta Saolini Paolo E. Puddu

A 59-year old woman was admitted at emergency for palpitation and dizziness. Medication history showed trimebutine 450 mg daily, because of meteorism, increased to 450 mg TID a week earlier. At admittance, sustained monomorphic ventricular tachycardia was interrupted by 100 mg intravenous lidocaine and a largely prolonged QTc (523 ± 12 ms) was seen. Discontinuation of trimebutine achieved norma...

Journal: :Environmental Health Perspectives 1976
M R Franklin

The effects of methylenedioxyphenyl insecticide synergists on human health arise, not from their intrinsic toxicity which is relatively low, but from their dual effect on the oxidative detoxication or intoxication processes of the body. They are able to inhibit these reactions by two mechanisms. They are substrates for mixed function oxidation and, thus, compete with other xenobiotics for avail...

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