CD44 is a ubiquitous cell-surface glycoprotein that displays many variant isoforms (CD44v) generated by alternative splicing of exons 2v to 10v. The expression of variant isoforms is highly restricted and correlated with specific processes, such as leukocyte activation and malignant transformation. We have herein studied CD44v expression in acute myeloid leukemia (AML) and, for comparison, in n...

3 Introduction 3 Materials and Methods 5 Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Deep Neural Networks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Deep Neural Network Architecture . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Experimental Setup . . . . ...

A harmonic mixer for direct-conversion receivers is proposed and fabricated in a CMOS process. It is immune from both the flicker noise and self-mixing induced DC offset. Using the lateral bipolar transistor and the harmonic mixing technique, it achieves +15dB gain, 17.8dB NF at 10kHz frequency, 8.2dBm IIP3, +44dBm IIP2 and more than 30dB DC offset suppression. It consumes 2.2mW power at 3V.

We assign the 2v(3) ? v(3) absorption transitions seen in a double-resonance pump-probe experiment. We compare the observed frequencies with those derived by calculating the 2v(3) rovibrational energy levels, using spectroscopic constants resulting from a 3v(3) analysis. Some features in the multiple-photon v(3) absorption spectrum of SF(6) can be attributed to two-photon transitions to 2v(3).

CD44 variant isoforms (CD44v) are generated by alternative splicing of the nuclear RNA resulting in the expression of additional protein domains in the extracellular region of the CD44 standard molecule (CD44s). In multiple myeloma (MM), CD44 mediates binding of tumor cells to stroma and regulates interleukin-6 production. To evaluate the role of CD44v isoforms in MM, CD44v expression was analy...

[Purpose] The purpose of this study was to examine the reliability of three isometric knee extension strength measurements (IKE) made with a hand-held dynamometer (HHD) and a belt of healthy elderly living in the community as subjects. [Subjects] The subject cohort consisted of 186 healthy elderly people, aged 65 to 79 years, living in local communities. [Methods] IKE of the leg subjects used t...

The well-known 3V architectural paradigm for Big Data introduced by Laney (2011) provides a simplified framework for defining the architecture of a big data platform to be deployed in various scenarios tackling processing of massive datasets. While additional components such as Variability and Veracity have been discussed as an extension to the 3V model, the basic components (Volume, Variety, a...

Background One rationale for including patient global assessment (PtGA) in Boolean remission is that PtGA ≤1 reduces the probability of joint findings outside 28 joints and complements limitations 28-joint count [1]. Meanwhile, criterion has been questioned, leading to establishment Boolean2.0 or proposal 3V-remission [2-3]. However, significance as a complement forgotten. Objectives This study...