allergic rhinitis  (ar) is  an  inflammatory  disorder  of  the  nasal  mucosa  with  high morbidity and prevalence. natural killer (nk) cells might have a role in ar. we aimed to evaluate the changes of the markers and receptors on nk cells in ar patients compared to the non-atopic controls. flow  cytometric  analysis was  used  with  double  staining  of  the  peripheral  blood mononuclear ce...

background helicobacter pylori multiplies and causes infection in human gastric mucosal layer. new approaches have focused on using specific treatments, such as immunotherapy, to limit this infection. urease, as one of the most important virulent and antigenic factors of the bacterium, is a suitable target for this purpose. patients and methods in order to prepare recombinant proteins, the synt...

background and aims. vascular endothelial growth factor (vegf) and ki-67 antigen are contributing factors in this process cell proliferation and new blood vessels formation in tumor progression. this study was conducted to examine the relationship between the expression of vegf and ki-67 and gender and age of patients with oral squamous cell carcinoma (oscc). materials and methods. twenty-three...

we report a case of florid polypoid endometriosis presenting with advanced bulky disease in pelvis with serum ca – 125 levels of 7844u/ml. the extent of tumor, ct scan findings, elevated serum ca – 125 levels were suggestive of ovarian malignancy. histopathology demonstrated endometrial glands and stroma. glands were neither crowded nor complex and were separated by a fibromatous stroma that co...

hydatid cyst, the larval stage of cestodes echinococcus spp., is recognized as a zoonotic infection in the world. the world health organization (who) has recently classified echinococcosis in a group of neglected tropical diseases.the prevalence of echinococcus granulosus infection is high in iran due to the presence of various intermediate hosts in this country. considering the rising trend of...

background prostate is an important male reproductive system gland and its disorders can affect men's quality of life and health. prostatitis, benign prostatic hyperplasia (bph), and prostate adenocarcinoma are major disorders that can be found in all men in different ages. objectives the aim of this study was to investigate the association of diet with serum prostate specific antigen (psa) lev...

Idecabtagene vicleucel (ide-cel, also called bb2121), a B-cell maturation antigen–directed chimeric antigen receptor (CAR) T-cell therapy, has shown clinical activity with expected CAR toxic effects in patients relapsed and refractory multiple myeloma.

Background Tumor markers have been a valuable tool for decades to aid in the diagnosis, treatment, and monitoring of oncological diseases.
 Objective To retrospectively analyze requisition pattern tumor marker requests at largest tertiary care center eastern Nepal.
 Method A retrospective hospital-based cross-sectional study was conducted obtain data 5 common i.e., Alpha-Fetoprotein (...

A range of cationic delivery systems have been investigated as vaccine adjuvants, though few direct comparisons exist. To investigate the impact platform, we prepared four (emulsions, liposomes, polymeric nanoparticles and solid lipid nanoparticles) all containing equal concentrations dimethyldioctadecylammonium bromide in combination with Neisseria adhesin variant 3 subunit antigen. The formul...

Excretory/Secretory antigen was prepared by culturing live adult worms of Haemonchus contortus in RPMI 1640 medium at a concentration of 50 worms per mL in a culture-flask at 37 ˚C for 24 hr and the culture supernatant was used as antigen. The E/S antigen was purified by thiol-sepharose affinity chromatography. On western blot analysis, it was demonstrated that thiol-purified antigen showed a s...