Wound Healing and Antioxidant Activities of Morinda Citrifolia Leaf Extract In Rats

Morinda citrifolia (Noni) has been traditionally used for bone and wound healing. &nbsp; The present study was carried out to investigate the effect of Morinda citrifolia leaves on experimental wounds and lipid peroxide levels in rats. Effect of aqueous extract of leaves of Morinda citrifolia (200 mg/kg) on excision, resutured incision and dead space wound models were studied. Measurement of blood malondialdehyde (MDA) levels and histopathological studies were also carried out. There was a significant increase (p<0.0001) in wound contraction rate, tensile strength, granuloma breaking strength, collagen content, dry granuloma weight (p<0.01) and hydroxyproline content. A significant decrease (p<0.0001) in epithelialisation period and MDA levels in Morinda citrifolia leaf extract treated group were observed when compared to control group. From the results, it may be concluded that the M. citrifolia aqueous leaves enhances the wound healing and possess antioxidant activity.