What Is the Main Reason of Shortening Duration of Action of Local Anesthetics Used for Spinal Anesthesia in Opium Addicted Patients?
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What Is the Main Reason for Reduction in Duration of Action of Local Anesthetics Used for Spinal Anesthesia in Opium Addicted Patients?
According to recent studies, in opioid abusers, compared with non-addicts, spinal anesthesia with local anesthetics has been accompanied with shorter duration of action and lower level of sensory block.1-4 Thus, it seems that chronic opiate abuse can produce tolerance, or probably, crosstolerance to analgesic effects of local anesthetics. As yet, no clear explanation has been presented for this...
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The primary mode of action of local anesthetics is through sodium channel and axonal conduction blockade. Local anesthetics have also extensive effects on pre-synaptic calcium channels that must function to stimulate the release of neurotransmitters. Thus, interference with calcium channel conductance may enhance spinal anesthesia with local anesthetics. The present study was designed to invest...
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عنوان ژورنال
دوره 7 شماره 3-4
صفحات 198-
تاریخ انتشار 2015-08-08
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