Treatment effect of GABA on improve type one diabetes in NOD mice

Introduction: Gama amino butyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian nervous system. The concentration of GABA and the number of GABA cell secretion decrease in diabetic patient and experimental diabetes model. The reported effects of GABA activation on insulin secretion from beta cells have been controversial. In this study we investigated if GABA administration in animal diabetes model can change insulin and glucagon secretion and improve some diabetic symptoms. Methods: Twenty fourth-week old NOD mi(Non obese diabetic mice) ce were used. Two months after diabetic induction animals were divided into the two groups. One group received 200 μmol of GABA and the other group received phosphate buffer solution (PBS) for one month. Results: GABA administration could significantly decrease plasma glucose and glucagon level, water consumption and urine volume and body fat distribution in the mesenteric bed and abdominal wall. It also could increase plasma Cpeptide level and it has not effect on food intake. Conclusion: NOD mice is very good genetically model for type one diabetes and GABA administration in this mice could treatment some of diabetic symptom. It seems may be we could use of GABA for treatment of diabetic symptom in future. Keywords: Type one diabetes, GABA, C-peptide, Glocagon, glucose, NOD mice.