To What Extent Vital Signs Are Important to Medical Toxicologists When Conflicts Arise in Defining Toxidroms

phosphate metabolism modulation in chronic kidney disease: when, how and to what extent?

What is 'normal?' Evaluating vital signs.

PROBLEM Vital sign (VS) assessment and monitoring are often routinely scheduled whether they are needed or not. This practice led pediatric nurse leaders to voice concerns about the frequency of VS at a National Summit for Pediatric and Adolescent Evidence-Based Practice. A search of databases yielded no direct evidence regarding frequency. However, we determined that before this question could...

Minimal clinically important difference: defining what really matters to patients.

When assessing the clinical utility of therapies intended to improve subjective outcomes, the amount of improvement that is important to patients must be determined.1 The smallest benefit of value to patients is called the minimal clinically important difference (MCID). The MCID is a patient-centered concept, capturing both the magnitude of the improvement and also the value patients place on t...

Hormesis: why it is important to toxicology and toxicologists.

This article provides a comprehensive review of hormesis, a dose-response concept that is characterized by a low-dose stimulation and a high-dose inhibition. The article traces the historical foundations of hormesis, its quantitative features and mechanistic foundations, and its risk assessment implications. The article indicates that the hormetic dose response is the most fundamental dose resp...

What are the Most Important Features to Individualize: Extending Knowledge Tracing to Individualize What is Important

One traditional way of modeling student knowledge is Corbett and Anderson Knowledge Tracing [2]. Knowledge Tracing model learns a set of four parameters per skill known in the field as 1) Prior (allowing for the modeling of the average chanced that students know a given skills before starting with the system), 2) Learn (different skills could have different learning rates), 3) Guess (some skill...

Vital signs.

9 15 36 Nerve center: I told the neurologist, 'I'm having a stroke. These are my symptoms.' I wasn't all upset about it. Needle and the damage done: In my 25 years of doing substance abuse research here I've never seen anything like this… Age old question: How old is your skeleton? It seems like a simple question. As old as you are, right? Not exactly. In this edition of Vital Signs, we tackle ...