Three antioxidant phenylethanoid glycosides from the rhizomes of Eremostachys pulvinaris (family: Labiatae)
نویسندگان
چکیده مقاله:
Eremostachys pulvinaris (family: Labiatae), one of the 60 species of the genus Eremostachys, occurs mainly in central Asian countries, e.g. Iran, Armenia, Ashgabad and the USSR. The rhizomes of this plant were collected from Tabriz in Azarbaijan province during September-October 2003. There is no report on any previous phytochemical investigation on E. pulvinaris available todate, phytochemical studies on a few other species of Eremostachys revealed the presence of flavonoids and monoterpene glycosides The dried and ground rhizomes of E. glabra (100 g) were Soxhlet-extracted, successively, with n-hexane, dichloromethane and methanol. The preparative reversed-phase HPLC analysis of the 40% methanolic Sep-Pack fraction resulted in the isolation of three phenylethanoid glycosides. The free radical scavenging activity and general toxicity of these compounds have been assessed. The chemical structures of these compounds (forsythoside B, leucosceptoside A and verbascoside) have been elucidated by by UV, ESIMS, and comprehensive 1D and 2D NMR analyses including COSY, NOESY, HMQC and HMBC., and also by comparing experimental data with respective literature data. While none of these compounds has shown any significant general toxicity in the brine shrimp lethality assay (LD50>1 mg/mL), forsythoside B, leucosceptoside A and verbascoside have displayed significant antioxidant activity in the DPPH assay (RC50 = 0.0064, 0.0148 and 0.0079 mg/mL, respectively). This is the first report on the occurrence of phenylethanoid glycosides in E. glabra and also in the genus Eremostachys. Isolation and identification of these compounds from the rhizomes of E. glabra of the family Lamiaceae might be chemotaxonomically significant
منابع مشابه
Iridoid and Furanolabdane -Type Diterpene Glycosides from Rhizomes of Eremostachys azerbaijanica Rech. f.
Background and objectives: The rhizomes of Eremostachys azerbaijanica Rech. f.,as an indigenous plant in East Azerbaijan province of Iran, were studied for isolation and identification of possible phytoconstituents. Methods: The air- dried and ground rhizomes were extracted with n-hexane, dichloromethane (DCM) and methanol (MeOH) using a Soxhlet appara...
متن کاملThree New Sesquiterpene Glycosides from the Rhizomes of Trillium tschonoskii.
Three new sesquiterpene glycosides, possessing a rare aglycone with a sulfonyl between C-1 and C-15 positions, named 3-(3'E-7'R,8'-dihydroxy-4',8'-dimethyl-3'-nonenyl)-2,5-dihydro-1,1-dioxo-thiophen 7'-O-β-d-glucopyranosyl-(1→4)-O-β-d-glucopyranosyl-(1→4)-O-β-d-glucopyranoside (1), 3-(3'E-7'R,8'-dihydroxy-4',8'-dimethyl-3'-nonenyl)-2,5-dihydro-1,1-dioxo-thiophen 7'-O-β-d-glucopyranosyl-(1→4)-O-...
متن کاملPhenylethanoid Glycosides from Digitalis viridiflora
From the MeOH extract of the leaves of Digitalis viridiflora five phenylethanoid glycosides (1-5) including a new one were isolated. The structure of the new compound was established as 3,4-dihydroxy-βphenylethoxy-O-β-quinovopyranosyl-(16)-4-O-caffeoyl-β-glucopyranoside (viridifloroside, 1) based on extensive 1Dand 2D-NMR spectroscopy as well as MS. Compound 1 is the first example of a phenyle...
متن کاملIridoid and Phenylethanoid Glycosides from Verbascum lasianthum
were isolated from the roots of Verbascum lasianthum Boiss. ex Bentham. In addition, 2 phenylethanoid glycosides, verbascoside {=acteoside, [β-(3,4-dihydroxyphenyl)-ethyl]-(3′-O-α-L-rhamnopyranosyl)-(4′ O-caffeoyl)-β-D-glucopyranoside} (4) and poliumoside {= [β-(3,4-dihydroxyphenyl)-ethyl]-(3′,6′-O-αL-dirhamnopyranosyl)-(4′ -O-caffeoyl)-β-D-glucopyranoside} (5), were also isolated. The structur...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره Volume 3 شماره Supplement 2
صفحات 23- 24
تاریخ انتشار 2010-11-20
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023