The Role of Mas Receptor and Bradykinin on Nitric Oxide Production Response to Angiotensin 1-7 in Ovariectomized Rats Treated with Estradiol
نویسندگان
چکیده مقاله:
Introduction: The angiotensin 1-7 (Ang1-7) Mas receptor (MasR) axis, bradykinin (BK) and female sex hormone are involved in releasing of vasodilatory biomarkers including Nitric Oxide (NO). We examined the role of MasR and BK on NO metabolite (nitrite) production response to Ang 1-7 infusion in ovariectomized rats treated with estradiol. Methods: A total of 48 female Wistar rats were divided into 2 main groups; ovariectomized treated with placebo (OVX) and ovariectomized treated with estradiol valerate (OVE) for period of two weeks. Then after anesthetization, the animals of each groups were divided into four subgroups that received MasR antagonist (A779) or , BK, BK+A779 or vehicle, and they were subjected to Ang1-7 infusion (0, 100, 300 and 1000 ng/kg/min). The level of nitrite (NO metabolite) was measured by Griess method. Results: The serum level of nitrite response to Ang 1-7 administration in OVE group was incrased when compared with OVX group, however when MasR was blocked by A799, the increased nitrite level was abolished. BK also increased the level of nitrite but co administration of BK and A779 did not enhance the nitrite level in both OVE and OVX groups. Conclusion: Estradiol and Bk increase nitrite production in response to Ang 1-7 infusion in condition of MasR presence.
منابع مشابه
role of mas receptor in renal blood flow response to angiotensin-(1-7) in ovariectomized estradiol treated rats
the angiotensin 1-7 (ang 1-7), is abundantly produced in kidneys and antagonizes the function of angiotensin ii through mas receptor (masr) or other unknown mechanisms. in the current study, the role of masr and steroid hormone estrogen on renal blood flow response to ang 1-7 administration was investigated in ovariectomized (ov) female rats. ov female wistar-rats received estradiol (500 µg/kg/...
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Background and purpose: Chronic kidney disease is among the common diseases in the world. Studies show that women are more protected against renal diseases compared to men. On the other hand, vasodilatory axises of renin angiotensin system (angiotensin 1-7 (Ang 1-7)- Mas receptor (MasR)), kallikrein-kinin, and nitric oxide (NO) play key roles in kidney function and circulation in females. There...
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متن کاملRole of Mas Receptor Antagonist A799 in Renal Blood Flow Response to Ang 1-7 after Bradykinin Administration in Ovariectomized Estradiol-Treated Rats
Background. The accompanied role of Mas receptor (MasR), bradykinin (BK), and female sex hormone on renal blood flow (RBF) response to angiotensin 1-7 is not well defined. We investigated the role of MasR antagonist (A779) and BK on RBF response to Ang 1-7 infusion in ovariectomized estradiol-treated rats. Methods. Ovariectomized Wistar rats received estradiol (OVE) or vehicle (OV) for two week...
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Bradykinin B2 receptor (B2R) and angiotensin-(1-7) Mas receptor (MasR)-mediated effects are physiologically interconnected. The molecular basis for such cross talk is unknown. It is hypothesized that the cross talk occurs at the receptor level. We investigated B2R-MasR heteromerization and the functional consequences of such interaction. B2R fused to the cyan fluorescent protein and MasR fused ...
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عنوان ژورنال
دوره 22 شماره None
صفحات 12- 17
تاریخ انتشار 2018-01
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