The role of GABAA receptors in the analgesic effect of intra-paragigantocellularis lateralis injection of 17β-estradiol in male rat

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چکیده مقاله:

Introduction: 17&beta-Estradiol modulates nociception by binding to the estrogenic receptors and also by allosteric interaction with other membrane-bound receptors like glutamate and GABAA receptors. In addition to its autonomic functions, paragigantocellularis lateralis (LPGi) is involved in the pain modulation, too. The aim of the current study was to investigate the involvement of the membrane-bound GABAA receptors in the pain modulatory effect of intra- LPGi injection of 17&beta-estradiol of male rats. Materials and Methods: This study was performed using male Wistar rats in the range of 200-270 g. In order to investigate the antinociceptive effect of intra-LPGi microinjection of 17&beta-estradiol, cannulation into the LPGi nucleus was performed. 500 nl of drugs were administered 15 minutes prior to formalin injection (50 &mul of 4%). Then, formalin-induced paw jerking behaviour was recorded for 60 min. For assessing the role of the GABAA receptors in the estradiol induced pain modulation, 17&beta-estradiol was administered into the LPGi nucleus 15 min after the injection of 25 ng/&mul bicuculline and paw jerking frequency was recorded for 1 h. Results: The results of the current study showed that intra-LPGi injection of 0.8 &mumol of 17&beta-estradiol attenuated the chronic phase (P<0.001) of paw jerking behaviour. Bicuculine -the GABAA receptor antagonist- significantly reduced the antinociceptive effect of intra-LPGi 17&beta-estradiol in the chronic phase (P<0.001). Conclusion: It may be concluded that the analgesic effect of intra-LPGi injection of 17&beta-estradiol on the formalin-induced inflammatory pain might be mediated via GABAA receptors.

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the role of gabaa receptors in the analgesic effect of intra-paragigantocellularis lateralis injection of 17β-estradiol in male rat

introduction: 17&beta-estradiol; modulates nociception by binding to the estrogenic receptors and also by allosteric interaction with other membrane-bound receptors like glutamate and gabaa receptors. in addition to its autonomic functions, paragigantocellularis lateralis (lpgi) is involved in the pain modulation, too. the aim of the current study was to investigate the involvement of the membr...

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Analgesic Effect of 17β-Estradiol on Nucleus Paragigantocellularis Lateralis of Male Rats Mediated Via GABAA Receptors

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Analgesic Effect of 17β-Estradiol on Nucleus Paragigantocellularis Lateralis of Male Rats Mediated Via GABAA Receptors

INTRODUCTION Beside its autonomic functions, the nucleus paragigantocellularis lateralis (LPGi) is involved in the descending pain modulation. 17β-Estradiol is a neuroactive steroid found in several brain areas such as LPGi. Intra-LPGi microinjection of 17β-estradiol can elicit the analgesic responses. 17β-Estradiol modulates nociception by binding to estrogenic receptors as well as allosteric ...

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Assessing the effect of intra-paragigantocellularis lateralis injection of 17β- estradiol on the acute and persistent pain in the male rat

Introduction: 17β-estradiol modulates nociception by binding to estrogenic receptors and also by allosteric interaction with other membrane-bound receptors like glutamate and GABAA receptors. Beside its autonomic functions, paragigantocellularis lateralis (LPGi) nucleus is also involved in pain modulation. The aim of the current study was to investigate the role of the intracellular estrogen...

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The antinociceptive effect of 17β-estradiol in the paragigantocellularis lateralis of male rats is mediated by estrogenic receptors

Introduction: 17β-Estradiol is a neuroactive steroid and its pain modulatory role has been well studied previously. 17β-Estradiol modulates nociception by binding to its receptors and also by allosteric interaction with other membrane - bound receptors such as glutamate and GABAA receptors. Paragigantocellularis lateralis (LPGi) is also involved in pain modulation and perception, in addition...

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عنوان ژورنال

دوره 19  شماره None

صفحات  99- 106

تاریخ انتشار 2015-05

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