The Relation between Left Ventricular Function and Serum Ferritin in Major Β-Thalassemia
نویسندگان
چکیده مقاله:
Abstract Objective Cardiac dysfunction is a major cause of death in patients with beta thalassemia. In these patients, repeated blood transfusion, ineffective erythropoiesis and increased gastrointestinal iron absorption lead to iron overload in the body and this induced heart failure. Left ventricular ejection fraction was measured in major beta thalassemia (β-Th) patients to detect the relation of serum ferritin level and left ventricular systolic function. Materials and Methods The present prospective study evaluated 75 patients with β-thalassemia (39 female, 36 male) aged one to 44 years old. They were treated with desferal 5 days a week for at least six months. For this study they treated by desferal 7 days a week. Left ventricular ejection fraction and serum ferritin were measured before and after intervention, and they were compared for the best treatment. Results The mean ejection fraction was 60.45% and 62.9% before and after aggressive therapy, which difference was significant. Serum ferritin level also was reduced after intervention. Difference between mean ferritin before and after intervention was 49.984. Serum ferritin showed negative correlation with left ventricular function. Conclusion Lower serum ferritin concentration with aggressive therapy was associated with better left ventricular function.
منابع مشابه
the relation between left ventricular function and serum ferritin in major β-thalassemia
abstract objective cardiac dysfunction is a major cause of death in patients with beta thalassemia. in these patients, repeated blood transfusion, ineffective erythropoiesis and increased gastrointestinal iron absorption lead to iron overload in the body and this induced heart failure. left ventricular ejection fraction was measured in major beta thalassemia (β-th) patients to detect the relati...
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Abstract Background Prevention of myocardial siderosis is a key step to reduce rate of mortality in thalassemic patients. Our objective was to study association between echocardiography parameters and serum ferritin level in patients with major thalassemia. Materials and Methods Sixty-six patients with major thalassemia were studied in Amir Kabir hospital, Arak, Iran. Serum ferritin levels ...
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متن کاملCorrelation of Serum Ferritin Level with Cardiac Function in β-Thalassemia Major
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عنوان ژورنال
دوره 1 شماره 3
صفحات 94- 97
تاریخ انتشار 2011-09
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