The effects of nano-silver and garlic administration during pregnancy on neuron apoptosis in rat offspring hippocampus

نویسندگان

  • Ali Reza Ebrahimzadeh-bideskan Department of Anatomy and Cell biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Maryam Lale Ataei Department of Anatomy and Cell biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده مقاله:

Objective(s):The aim of this study was to investigate the effects of nano-silver and garlic administration during pregnancy on neuron apoptosis in rat offspring hippocampus. Materials and Methods: Fifty pregnant wistar rats were randomly divided into five groups: 1- nano- silver (N.S) group; 30 mg/kg of N.S treated via gavage. 2- Control (C) group, administrated with distilled water via gavage. 3- N.S and garlic (N.S+G) group; N.S (30 mg/kg) and garlic juice (1 ml/100 g) treated via gavage simultaneously. 4- Garlic group (G); garlic juice (1 ml/100 g) administrated via gavage, 5- normal (N) without any intervention. All the interventions were done during pregnancy (21 days). Finally, the brains of rat offspring were removed to use for nano-silver level measurement and TUNEL staining. The mean of TUNEL positive cell numbers per unit area (NA) in different regions of hippocampus were compared in all animal groups. Results: The results revealed a significant increase of hippocampus nano-silver level in N.S and N.S+G groups comparing to N group (P

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the effects of nano-silver and garlic administration during pregnancy on neuron apoptosis in rat offspring hippocampus

objective(s):the aim of this study was to investigate the effects of nano-silver and garlic administration during pregnancy on neuron apoptosis in rat offspring hippocampus. materials and methods: fifty pregnant wistar rats were randomly divided into five groups: 1- nano- silver (n.s) group; 30 mg/kg of n.s treated via gavage. 2- control (c) group, administrated with distilled water via gavage....

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عنوان ژورنال

دوره 17  شماره 6

صفحات  411- 418

تاریخ انتشار 2014-06-01

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