The effect of scalp cooling system by penguin cold cap therapy system in preventing chemotherapy induced alopecia in cancer patients, Shiraz-2004

Introduction: Alopecia has been established as the most bothersome aspect of preoperative chemotherapy. Some patients even refrain from cytotoxic treatment. This is an experimental study evaluating the efficiency of scalp cooling system&nbsp; preventing chemotherapy induced alopecia in cancer patients in an oncology clinic in Shiraz, Iran. Methods: A total number of 63 (male / female, 23/40) patients participated in the study and (mean age=35Y) (16-59) were treated every 3 weeks for six weeks with an Ivregimen of chemotherapy drug. 31 patients accepting the scalp-cooling system were compared for alopecia with those who refused the scalp cooling system consisting of 32 patients similarly treated but without being offered a scalp cooling system. Hair loss in the patients was evaluated by nurses using World Health Organization (WHO) criteria at each cycle of chemotherapy. Results: In this study, the differences between the two groups were statistically significant at cycles 2-6 (p<0.05). Tolerance was generally good. In the study group in the 2nd cycle, 77.4% of the patients belonged to 1st and 2nd grade of alopecia. No 4th grade was observed in the group. However, in the control group in the same cycle, 61.3% of the patients were in the 3rd and 4th grade of alopecia.&nbsp; Also, in the 6th cycle 40% of the study group and 68.8% of the control group showed the 4th grade of alopecia. Conclusion: In the long-run, the patient is spared the tedious search for and expense of a wig or other forms of head coverings. Ultimately damage to hair follicle cells is minimized, hair loss is prevented or significantly reduced and the patient&rsquo;s self image is maintained. Therefore, diminishing the pernicious effects the penguin cold cap therapy has proven highly successful. But it is important to remind the patients that it is not successful in all cases and this depends on the individual characteristics, liver function, and drug regimen. &nbsp;