The effect of natural adjuvants (G2, G2F) on lung inflammation of sensitized guinea pigs
نویسندگان
چکیده مقاله:
Objective: The effects of natural adjuvants were examined on total and differential WBC counts in lung lavage of sensitized guinea pigs. Materials and Methods: In three sensitized groups of guinea pigs including: untreated sensitized animals (S), sensitized animals treated with adjuvant G2 (S+G2) and G2F (S+G2F) as well as non-sensitized group (C) (n=6 for each group), total and differential WBC counts of lung lavage were examined. Sensitization of animals was achieved by injection and inhalation of ovalbumin (OA). Results: The results showed increased total WBC, eosinophil, neutrophil, and basophil counts, and decreased lymphocytes in lung lavage of sensitized animals compared with the control group (pConclusion: These results indicate important preventive effects of two natural adjuvants, especially G2, on lung inflammation of sensitized guinea pigs.
منابع مشابه
the effect of natural adjuvants (g2, g2f) on lung inflammation of sensitized guinea pigs
objective: the effects of natural adjuvants were examined on total and differential wbc counts in lung lavage of sensitized guinea pigs. materials and methods: in three sensitized groups of guinea pigs including: untreated sensitized animals (s), sensitized animals treated with adjuvant g2 (s+g2) and g2f (s+g2f) as well as non-sensitized group (c) (n=6 for each group), total and differential wb...
متن کاملThe Effect of the Natural Adjuvants on Cell Count in Lung Lavage of Sensitized Guinea Pigs
Airway inflammation is the most characterized pathological feature in asthma. The antiinflammatory effect of the adjuvants is reported. Therefore, the effect of two different natural adjuvants on white blood cells (WBC) of lung lavage of sensitized guinea pigs were examined. White blood cells count and differential WBC of lung lavage were examined in control and 3 groups of guinea pigs includin...
متن کاملThe preventive effects of natural adjuvants, G2 and G2F on tracheal responsiveness and serum IL-4 and IFN-γ (th1/th2 balance) in sensitized guinea pigs
OBJECTIVE The effects of natural adjuvants on lung inflammation and tracheal responsiveness were examined in sensitized guinea pigs. METHODS The responses of guinea pig tracheal chains and the serum levels of interleukin-4 and interferon-gamma were examined in control pigs and three other groups of guinea pigs: the sensitized group and two other sensitized groups treated with either adjuvant ...
متن کاملthe effect of natural adjuvants on pathological changes in sensitized guinea pig lungs
conclusions: these results indicate preventive effects of all natural adjuvants (especially g2) on pathological changes of the lung in sensitized guinea pigs. results: all pathological changes in s group including the eosinophil infiltration (scoring 3.28 ± 0.28), lymphocyte infiltration (2.82 ± 0.26), local epithelial necrosis (2.71 ± 0.47) and mucosal plug (2.75 ± 0.37) were significantly hig...
متن کاملThe Effect of Natural Adjuvants on Pathological Changes in Sensitized Guinea Pig Lungs
BACKGROUND Anti-inflammatory effect of natural adjuvants has been reported. Lung inflammation is the most characterized pathological feature in asthma. OBJECTIVES The effects of three natural adjuvants (PC, G2, and G2F registered as a patent in the Iranian Patent Office) on sensitized guinea pigs lungs were examined in the present study. MATERIALS AND METHODS LUNG PATHOLOGICAL CHANGES WERE ...
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عنوان ژورنال
دوره 3 شماره 4
صفحات 364- 370
تاریخ انتشار 2013-09-01
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