The Effect of HLA-DRB1 Sharing between the Couples with Recurrent Pregnancy Loss on the Pregnancy Outcome after Leukocyte Therapy

نویسندگان

  • Behrouz Gharesi-Fard Infertility Research Center | Department of Immunology, School of Medicine | Proteomics Laboratory, School of Advanced Medical Sciences and Technologies,
  • Rahil Askarinejad-Behbahani Student Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Shabnam Behdin Student Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده مقاله:

Background: Miscarriage is a common phenomenon complicating more than half of pregnancies. Recurrent Pregnancy Loss (RPL) is defined as three or more pregnancies lost before the twentieth week of gestation. It is believed that abnormality in maternal immune reaction to fetus and sharing of HLA antigens might be associated with RPL. Objective: To investigate the effect of HLA-DRB1 sharing between the couples with recurrent pregnancy loss on the pregnancy outcome after leukocyte therapy. Methods: Sixty primary RPL women who were immunized and followed after therapy (30 successful and 30 unsuccessful) and their husbands formed the cases of this study. In addition, one hundred healthy women were considered as the controls. HLA-DRB1 genotypes of all the cases and controls were checked by PCR-SSP method. Results: HLA typing indicated that the prevalence of HLA-DRB1 sharing (defined as at least one allele sharing) between the couples with unsuccessful outcomes was significantly higher compared to those with successful outcomes (63.3% vs. 23.3%, p

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the effect of hla-drb1 sharing between the couples with recurrent pregnancy loss on the pregnancy outcome after leukocyte therapy

background: miscarriage is a common phenomenon complicating more than half of pregnancies. recurrent pregnancy loss (rpl) is defined as three or more pregnancies lost before the twentieth week of gestation. it is believed that abnormality in maternal immune reaction to fetus and sharing of hla antigens might be associated with rpl. objective: to investigate the effect of hla-drb1 sharing betwee...

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The effect of HLA-DRB1 sharing between the couples with recurrent pregnancy loss on the pregnancy outcome after leukocyte therapy.

BACKGROUND Miscarriage is a common phenomenon complicating more than half of pregnancies. Recurrent Pregnancy Loss (RPL) is defined as three or more pregnancies lost before the twentieth week of gestation. It is believed that abnormality in maternal immune reaction to fetus and sharing of HLA antigens might be associated with RPL. OBJECTIVE To investigate the effect of HLA-DRB1 sharing betwee...

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عنوان ژورنال

دوره 11  شماره 1

صفحات  13- 20

تاریخ انتشار 2014-03-01

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