The effect of freeze-dried bone allograft and partially demineralized freeze-dried bone allograft on regeneration of rabbit calvarial bone defects: A Histological and histomorphometric study
نویسندگان
چکیده مقاله:
Background and Aims: Reconstruction of osseous defects is one of the ideal goals of periodontal treatments and dental implant therapy. Different biomaterials have been used for this purpose and many studies have tried to compare and introduce the best ones. The present study aimed to evaluate the effect of PDFDB (Partially Demineralized Freeze-Dried Bone Graft) and FDBA (Freeze Dried Bone Allograft) on the regeneration of rabbit calvarial defects. Materials and Methods: In this experimental study, 48 similar defects with the diameter of 8 mm were generated in the calvarium of 16 rabbits. Two defects were filled with FDBA and PDFDB, while the other one remained unfilled as the control group. All defects were covered by collagen membranes. 6 and 12 weeks after surgery, the histologic and histomorphometric tests were performed to evaluate the following variables: the rate of new bone formation and its type, the amount of residual grafting material, degree of inflammation and pattern of bone formation. Comparison of osteogenesis percentage and residual biomaterial was performed by repetitive variance analysis, whereas qualitative variables were compared by Friedman non-parametric test. Results: Regarding bone formation percentage, there was no statistically significant difference between three different groups at 6-week (P=0.33) and also at 12-week time points (P=0.98). The amount of residual material in the PDFDB group was significantly lower than FDBA (P=0.04) in the 6-week samples. However, this difference was not significant in the 12-week samples (P=0.41). Bone quality showed statistically significant difference between graft containing groups and control group after 12 weeks (P=0.01). It means, all samples in FDBA and PDFDB groups displayed lamellar bone after 12 weeks while in control group, only woven bone or a combination of woven and lamellar bone was seen. Conclusion: FDBA and PDFDB demonstrated similar regenerating effect in the rabbit calvarial bone defects and hastened bone maturation compared to the non-grafted defects.
منابع مشابه
comparison of bone regeneration using three demineralized freeze-dried bone allografts: a histological and histomorphometric study in rabbit calvaria
background: it has been stated that the bone allografts from different tissue banks may lead to various amount of bone induction, so the aim of this study was to evaluate bone regeneration of three demineralized allografts both histologically and histomorphometrically in rabbits calvaria bone defects. materials and methods: in this double-blind randomized experimental animal study, 32 critical ...
متن کاملSocket Preservation Using Freeze-Dried Bone Allograft with and without Simvastatin in Rats
Background and purpose: Today, implant treatment is one of the most popular dental treatments. To have a successful long-lasting implant treatment, enough bone is needed in that area. Given the positive effects of simvastatin on osteogenesis, this research aimed to compare the effect of freeze-dried bone allograft with and without simvastatin in extracted tooth socket in rats. Materials and me...
متن کاملDetermination of orthodontic tooth movement and tissue reaction following demineralized freeze-dried bone allograft grafting intervention
BACKGROUND Socket preservation after tooth extraction is one of the indications of bone grafting to enhance preorthodontic condition. The aim of this study is to determine the effects of socket preservation on the immediate tooth movement, alveolar ridge height preservation and orthodontic root resorption. MATERIALS AND METHODS In a split-mouth technique, twelve sites in three dogs were inves...
متن کاملComparison of the bone healing capacity of autogenous bone, demineralized freeze dried bone allograft, and collagen sponge in repairing rabbit cranial defects
J Korean Assoc Oral Maxillofac Surg 2012;38:221-30) Objectives: This study sought to evaluate the efficacy of collagen graft materials, as compared to other graft materials, for use in healing calvarial defects in rabbits. Materials and Methods: Ten mm diameter calvarial defects were made in ten rabbits. The rabbits were then divided into 4 groups: control, autogenous bone graft, SureOss graft,...
متن کاملIn vitro assay for osteoinductive activity of different demineralized freeze-dried bone allograft
PURPOSE Various bone graft materials have been used for periodontal tissue regeneration. Demineralized freeze-dried bone allograft (DFDBA) is a widely used bone substitute. The current widespread use of DFDBA is based on its potential osteoinductive ability. Due to the lack of verifiable data, the purpose of this study was to assess the osteoinductive activity of different DFDBAs in vitro. ME...
متن کاملdetermination of orthodontic tooth movement and tissue reaction following demineralized freeze-dried bone allograft grafting intervention
background: socket preservation after tooth extraction is one of the indications of bone grafting to enhance preorthodontic condition. the aim of this study is to determine the effects of socket preservation on the immediate tooth movement, alveolar ridge height preservation and orthodontic root resorption. materials and methods: in a split-mouth technique, twelve sites in three dogs were inves...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 32 شماره 3
صفحات 136- 145
تاریخ انتشار 2019-12
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
کلمات کلیدی برای این مقاله ارائه نشده است
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023