SYNTHESIS OF MOLECULARLY IMPRINTED POLYMER FOR DETERMINATION OF DILTIAZEM BY EXPERIMENTAL METHOD

Background & Aims: In this study, a magnetic molecular imprinted polymer was used to measure the diltiazem drug. Based on the structure and pharmaceutical agent group, methacrylic acid was selected as a monomer for Diltiazem. Ethylene glycol de-methacrylate and azobisisobutyronitrile were used as cross-linkers and polymerisation initiators, respectively. Also, chloroform was used as a porogenic solvent. In order to investigate the polymer absorption capacity, a high-performance liquid chromatography system was used which had an absorption capacity of 9.59 mg / g. This allows the measurement and analysis of this drug in biological fluids and separates them from various wastewater. Materials & Methods: Methacrylic acid (MAA), ethylene glycol de-methacrylic acid (EGDMA), and azobisisobutyronitrile (AIBN) were obtained from Sigma Aldrich while Diltiazem was obtained from Sobhan-Dar Company. Serum samples were prepared from the medical diagnostic laboratory in Urmia. High-performance liquid chromatography with UV detector was used to determine the concentration of drug in existing samples by experimental method. Results: The results indicate that this drug is well absorbed by the synthetic polymer, and shows the results of repeated etiology and re-use of this polymer for the drug. It is possible to use this polymer for 5-6 times and it has a capacity of 9.50 mg / g of drug per gram of polymer. Conclusion: Polymer molecular membrane can act as a good absorbent for absorbing and measuring this drug with respect to the structure of the drug. Therefore, methacrylic acid has been used as polymerization monomer and has shown good results for drug absorption. Keywords: Determination, Polymer Molecular Imprinted, Diltiazem