Sydenham's Chorea

Cerebral blood flow abnormalities in children with Sydenham's chorea: a SPECT study.

Functional imaging studies in patients with Sydenhams chorea have suggested brain perfusional abnormalities. In this study, we aimed to investigate the cerebral perfusion patterns of the cortical/subcortical structures by using Tc-99m hexamethylpropylenamine oxime single photon emission computed tomography in children with Sydenhams chorea, accompanied with magnetic resonance imaging and crania...

Huntington's chorea.

The pharmacological treatment of Huntington's chorea has been based on the use of neuroleptic drugs, on the hypothesis that there is a functional dopaminergic hyperactivity in this illness (Agid, 1975). More recently, after the observation of reduced cholinergic and GABAminergic activity at the striatal level in brains of choreic subjects (McGeer et al., 1973; Stahl and Swanson, 1974; Bird and ...

Sydenham's chorea.

Sydenham's chorea (SC) is a disorder of the central nervous system (CNS) characterized by sudden, involuntary, arrhythmic, clonic, and purposeless movements. SC appears to provide a model for understanding various neuropsychiatric dysfunctions. Its relationship with attentional deficits, obsessive-compulsive symptoms (OCS) as well as movement disorders provides support for the hypothesis of the...

Chorea Gravis

[Huntington's chorea].

The possibility that Huntington's chorea might be due to a genetically determined biochemical derangement has been raised on a number of occasions. In 1963,Kenyon and Hardy suggested that abnormalities of magnesium metabolism might account for some of the features of Huntington's chorea and in a group of patients investigated the cellular magnesium levels using the Szvenk-Fekete titration metho...

Huntington's chorea.

Huntington's chorea is an hereditary disorder of the central nervous system characterized by the appearance in adult life of progressive chorea and dementia, and inherited in single autosomal dominant fashion with complete penetrance. The essential pathological features of Huntington's chorea are a primary loss of cells in the caudate nucleus and the putamen, and similar involvement of the cere...