Survey of Protective Effect of Ghazzayaghi (Falcaria Vulgris) Extract Against Ethanol-Induced Peptic Ulcer in Rat

Purpose: Survey of protective effects of Ghazzayaghi (Falcaria vulgaris) extract against ethanol-induced peptic ulcer in rat. Materials and Methods: Thirty-five young male rats (NMRI); 200-250gr weight divided in to five groups (7 Rats/group), the groups were treated with: distilled water 10kg in Control negative group, 50mg/kg ranitidine in control positives group, and three case groups were treated with 50, 100, 150-mg/kg extract by gavages, all groups were treated with 50% ethanol (10 mg/kg), and after one hour, all rat were killed and dissected. The stomach cut in greater curvatures and ulcer index was defined. Then, the stomachs were fixed and after tissue processing, 5-6, mm sections prepared for H.E staining and histological study and microscopic ulcer index. Results: 70% ethanol extracts of Gazzayaghi with 50,100mg/kg body weight, significantly (P<0.05) decreased stomach ulcer index, and curative ratio for 50,100,150mg/kg were 55.9%, 76.9% and 80.25% respectively. Microscopic ulcer index with this three doses were reduced significantly (P<0.05) and curative ratio were 53.52%, 69.48% and 83.82% respectively. Conclusion: The plant extracts have effective protective effect against gastric ulcer induced by ethanol.