Spermatogonia stem cells: A new pluripotent source for repairment in regenerative medicine

Harnessing mechanobiology of human pluripotent stem cells for regenerative medicine.

Recent advances in human pluripotent stem cells (hPSCs) open new doors for therapeutics of motor neuron (MN)-associated neurodegenerative diseases. However, the MN differentiation process is not yet completely understood. In this Viewpoint, we stress the concept of designing synthetic cell culture surfaces with precisely controlled mechanical properties (such as rigidity) to improve the efficie...

Human Pluripotent Stem Cells in Cardiovascular Research and Regenerative Medicine

Heart disease is one of the leading causes of mortality worldwide. Because adult cardiomyocytes (CMs) lack the ability to regenerate, malfunctions or significant loss of CMs due to disease or aging can lead to cardiac arrhythmias, heart failure, and subsequently death. Heart transplantation for patients with end stage heat failure is limited by the number of donor organs available. Cell-based t...

Spermatogonial stem cells as a source for regenerative medicine

osting by E Abstract Several researchers have reported the derivation of multipotent cells from both mouse and human spermatogonial stem cells. These spermatogonia-derived stem cells show similarities with embryonic stem cells both for phenotype and functionality, indicating that these cells may be a promising alternative source for stem-cell based therapies in regenerative medicine. 2011 Middl...

Nonhuman Primate Induced Pluripotent Stem Cells in Regenerative Medicine

Among the various species from which induced pluripotent stem cells have been derived, nonhuman primates (NHPs) have a unique role as preclinical models. Their relatedness to humans and similar physiology, including central nervous system, make them ideal for translational studies. We review here the progress made in deriving and characterizing iPS cell lines from different NHP species. We focu...

Renal endogenous stem cells: a new source for regenerative medicine in preterms?

Induced Pluripotent Stem Cells-A New Foundation in Medicine.

Generation of induced pluripotent stem (iPS) cells using defined factors has been considered a ground-breaking step towards establishing patient-specific pluripotent stem cells for various applications. The isolation of human embryonic stem (ES) cells set the standard that pluripotent stem cells are attainable as potentially immortal cells for regeneration of many types of tissues. Different ap...