Single and Repeated Ultra–Rapid Detoxification Prevents Cognitive Impairment in Morphine Addicted Rats: A Privilege for Single Detoxification

Single and Repeated Ultra-Rapid Detoxification Prevents Cognitive Impairment in Morphine Addicted Rats: A Privilege for Single Detoxification

BACKGROUND Opioids have been shown to affect learning and memory processes. Different protocols of morphine withdrawal can substantially vary in their success to prevent opioid induced impairments of cognitive performance. In the present study, we report the effects of single and repetitive ultra-rapid detoxification (URD) on spatial learning and memory in morphine addicted rats. METHODS Morp...

ultrarapid opioid detoxification: current status in iran and controversies

Ultrarapid Opioid Detoxification: Current Status in Iran and Controversies

Implication for health policy/practice/research/medical education: URD is a contradictory issue in the field of addiction. This article reviews documents related to URD in the literature beside the experiences of the author. Conclusion of this article may be helpful in considering this type of detoxification in some specific groups of addicts. Copyright © 2013, Zahedan University of Medical Sci...

The Effect of Vitamin E and Selenium on Cyclophosphamide Detoxification in Hepatic Tissues of Mature Rats

Introduction and Objective: liver is an important body organ without which life is impossible. Cyclophosphamide is an alkylating agent widely used as an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. The present study aimed to find a suitable antioxidant and examine the effect of vitamin E and selenium on reducing the side effects of cyclophosphamide on liver as a vit...

Single-Setup-Multiple-Deliveries for a Single Supplier-Single Buyer with Single Product and Backorder

  This article investigates integrated production-inventory models with backorder. A single supplier and a single buyer are considered and shortage as backorder is allowed for the buyer. The proposed models determine optimal order quantity, optimal backorder quantity and optimal number of deliveries on the joint total cost for both buyer and supplier. Two cases are discussed: single-setup-singl...

Combination of analgesics (NSAIDS), baclofen, clonidine and a single dose of buprenorphine for heroin detoxification

Background: Heroin dependency is currently an alarming problem. Objective: To investigate the efficacy of combination of analgesics (NSAIDS), baclofen, clonidine and a single high dose of buprenorphine in heroin detoxification. Results: Administration of combination of, baclofen 75 mg, clonidine 0.2 mg, ibuprofen 1200 mg and a single 57 mg of buprenorphine is very effective for detoxification o...