Safety assessment of a new strain of Lactobacillus pentosus (IBRC=11143) as a candidate probiotic

Background: It is believed that the consumption of an adequate amount of live lactic acid bacteria (as probiotic) may improve the health of their host. Many strains of lactic acid bacteria are generally considered to be safe. However, some strains of these bacteria have shown some adverse effects. Objectives: This study aimed to investigate the safety of a new strain of Lactobacillus pentosus (IBRC=11143) in wistar rats. Methods: In this experimental study, both male and female wistar rats (n=6) were used. Subacute toxicity study (for 28 days) was conducted by oral administration of Lactobacillus pentosus to the animals. In each sex, one group received saline and the other two groups received the bacteria at doses of 1×108 and 1×109 CFU/rat. Results: No significant alteration in the liver and kidney tissues was seen. However, in both sexes, there were significant differences in urea and creatinine levels between the control and the experimental groups. Some of the blood parameters (Lymphocyte, RBC, HCT, and HB) also showed significant changes in the groups that received the bacteria. Moreover, a significant increase in ALP level was observed in male rats . Conclusion: The results indicate that Lactobacillus pentosus11143 is not completely safe like other Lactobacillus strains. Therefore, Lactobacillus pentosus11143 strain may not be a good choice as a probiotic for human consumption.