Report of a Case of Vitamin D Resitant Rickets Associated with Congenital Alopecia

Vitamin D resistant rickets with alopecia is a rather rare heritable disease probably caused by a different variety of metabolic disorder of this vitamin. Disturbances of protoplasmic and unclear receptors for vitamin D metabolites in bones and intestinal cells have been proposed as basic mechanism; Alopecia is attributed to hypersensitivity to vitamin D; very much like what usually appears in vitamin D intoxication.  We had a similar case in a 16 month old boy admitted to pediatric Department Loghman-e- Hospital. Clinical feature of rickets started at one year of age and alopecia at birth. Vitamin therapy in high doses did not improve the rickets nor alopecia during hospitalization.