Regulatory T Cells and Myeloid-Derived Suppressor Cells in Patients with Peptic Ulcer and Gastric Cancer
نویسندگان
چکیده مقاله:
Background: Regulatory T Cells (Tregs) and Myeloid-Derived Suppressor Cells (MDSCs) are two main regulatory cells modulating the immune responses in inflammation and cancer. Objective: To investigate and compare Tregs and MDSCs in peptic ulcer and gastric cancer. Methods: Patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (NUD, n=22), peptic ulcer disease (PUD, n=25), and gastric cancer (GC, n=27) according to their endoscopic and histopathological examinations. Helicobacter pylori infection was diagnosed by rapid urease test and histopathology. The number of peripheral blood CD4+CD25+FoxP3+Tregs and CD14+HLA-DR- MDSCs were determined in all patients, by flow cytometry. The number of FoxP3+ regulatory T cells was also determined by immunohistochemistry (IHC). Results: The percentage of peripheral blood Treg cells in both PUD )0.81 ± 0.39, p
منابع مشابه
regulatory t cells and myeloid-derived suppressor cells in patients with peptic ulcer and gastric cancer
background: regulatory t cells (tregs) and myeloid-derived suppressor cells (mdscs) are two main regulatory cells modulating the immune responses in inflammation and cancer. objective: to investigate and compare tregs and mdscs in peptic ulcer and gastric cancer. methods: patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (nud, n=22), peptic ulcer disease...
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عنوان ژورنال
دوره 13 شماره 3
صفحات 167- 177
تاریخ انتشار 2016-09-01
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