Psoriasis: Current Therapeutical Strategies

PD-related psychosis: pathophysiology with therapeutical strategies.

Parkinson's disease (PD) is a chronic, neurodegenerative disease with degeneration of the central dopaminergic neurons in the substantia nigra, leading to a depletion of dopamine (DA) in the striatum. This depletion causes the clinical hallmarks of this disease: bradykinesia, hypokinesia, rigidity, tremor and postural instability. Besides these well known motor symptoms, non-motor symptoms may ...

Current therapeutic options in psoriasis

Introduction Psoriasis is a chronic skin disorder, characterized by inflammatory and hyperproliferative processes. Globally, reports on the prevalence of psoriasis reveal major differences in terms of ethnicity and climate zone, ranging between 0 and 11.8% (Jacobson et al 2011). In Europe, psoriasis affects approximately 2-3% of the population. Psoriasis onset can occur at any age, including bi...

Future therapeutical strategies dictated by pre-clinical evidence in ALS.

Classic concepts on amyotrophic lateral sclerosis led to define the disease as a selective degeneration of upper and lower motor neurons. At present such selectivity is questioned by novel findings. For instance, the occurrence of frontotemporal dementia is now increasingly recognized in the course of ALS. Again, areas outside the central nervous system are targeted in ALS. In keeping with moto...

Pathophysiology of Psoriasis: Current Concepts

The word ‘psoriasis’, is derived from the Greek word “psora” meaning “itch” or “scurf” or “rash”, although most patients suffering from the condition do not complain of itching. It has been known since ancient times and was originally considered a type of leprosy. For quite some time now, it is one of the most common human skin diseases. Up to a few deca‐ des back, psoriasis was considered to b...

Cyclosporine as Monotherapy for Psoriasis in the Setting of Chronic HCV Infection: A Forgotten Therapeutical Option

BACKGROUND Treatment of psoriasis in the setting of chronic hepatitis C virus (HCV) infection is difficult, because standard therapies like methotrexate are associated with increased hepatic toxicity. Due to the HCV suppressive effect. Cyclosporine may represent a valid systemic alternative for psoriatic-HCV patients. OBJECTIVES In this study, we report the successful usage of intermittent cy...

cyclosporine as monotherapy for psoriasis in the setting of chronic hcv infection: a forgotten therapeutical option