Protective Effect of Delayed Ischemic Postconditioning on Embolic Stroke Complications in Female Rat

The Protective Effects of Ischemic Postconditioning against Stroke: From Rapid to Delayed and Remote Postconditioning.

The author reviews the protective effects of ischemic postconditioning, a recently emerging strategy with broad implications in the search for new treatments in stroke and myocardial ischemic injury. Ischemic postconditioning, which refers to a series of brief ischemia and reperfusion cycles applied immediately at the site of the ischemic organ after reperfusion, results in reduced infarction i...

Protective effect of ischemic postconditioning against hepatic ischemic reperfusion injury in rat liver

PURPOSE The efficiency of ischemic postconditioning (IPC) was evaluated in a rat model of ischemic liver. Concentration of survivin of liver tissue correlated with the degree of antiapoptosis, so survivin was estimated to evaluate the efficiency of IPC on ischemic reperfusion (IR) injury. METHODS Twenty-four healthy rats were divided to three groups (SHAM, IR, and IPC). Rats in the SHAM group...

Neuroprotective Consequences of Postconditioning on Embolic Model of Cerebral Ischemia in Rat

Protective effect of delayed remote limb ischemic postconditioning: role of mitochondrial KATP channels in a rat model of focal cerebral ischemic reperfusion injury

Delayed remote ischemic postconditioning (DRIPost) has been shown to protect the rat brain from ischemic injury. However, extremely short therapeutic time windows hinder its translational use and the mechanism of action remains elusive. Because opening of the mitochondria K(ATP) channel is crucial for cell apoptosis, we hypothesized that the neuroprotective effect of DRIPost may be associated w...

Protective effect of delayed treatment with low-dose glibenclamide in three models of ischemic stroke.

BACKGROUND AND PURPOSE Ischemia/hypoxia induces de novo expression of the sulfonylurea receptor 1-regulated NC(Ca-ATP) channel. In rodent models of ischemic stroke, early postevent administration of the sulfonylurea, glibenclamide, is highly effective in reducing edema, mortality, and lesion volume, and in patients with diabetes presenting with ischemic stroke, pre-event plus postevent use of s...

The protective effect of moderate alcohol consumption on ischemic stroke.

CONTEXT Moderate alcohol consumption has been shown to be protective for coronary heart disease, but the relationship between moderate alcohol consumption and ischemic stroke is more controversial. OBJECTIVE To determine the association between alcohol consumption and risk of ischemic stroke. DESIGN Population-based case-control study conducted between July 1993 and June 1997. SETTING Mul...