Prognostic molecular markers in hepatocellular carcinoma (Review article
نویسندگان
چکیده مقاله:
Hepatocellular carcinoma (HCC) is the 5th commonest malignancy worldwide and is the third most common cause of cancer-related death. The prevalence is different in the world. The ability to predict patients at higher risk of recurrence and with a poor prognosis would help to guide surgical and chemotherapeutic treatment according to individual risk. As understanding of hepatocarcinogenesis has increased, the myriad of genetic and molecular events that drive the hepatocarcinogenic disease process, including angiogenesis, invasion and metastasis, have been identified. With advances in understanding of tumor biology, interest in molecular biomarkers of carcinogenesis has grown, both in terms of their prognostic significance and also their potential as therapeutic targets. Several molecular markers with prognostic significance have been identified in HCC. Not only these molecules may allow accurate prediction of prognosis of patients with HCC and allow targeting of therapy, but they may also represent novel targets for therapeutic agents. The aim of this review was to examine the current knowledge regarding the prognostic role of the most important molecular biomarkers in HCC. In this article prognostic value of the following molecular markers is discussed: tumor suppressor genes oncogenes cell cycle regulators apoptotic regulators markers of angiogenesis markers of invasion and metastasis growth factors and receptors telomerase markers of genomic instability aneuploidy and markers of microsatellite instability.
منابع مشابه
Diagnostic and Prognostic Molecular Markers in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide, representing also the main cause of death among cirrhotic patients. In contrast to most other solid tumors, the underlying cirrhotic liver disease in HCC patients greatly impairs tumor related prognosis, conferring this neoplasm a unique situation, in which accurate prognostic prediction is a relevant and unmet need. Al...
متن کاملPrognostic and Predictive Clinical, Pathological and Molecular Markers for Oral Squamous Cell Carcinoma: review of articles
Approximately 90% of all head and neck malignancies and 94% of oral malignancies are squamous cell carcinoma (SCC). Tobacco smoking is considered as the most important causative agent for SCC. Despite aggressive and multidisciplinary treatment approaches, there has been no significant improvement in 5-year survival over the past 20 years. Several prognostic and predictive clinical, pathological...
متن کاملApplication of DNA Molecular Markers in Plant Breeding (Review article)
Plant Breeding has utilized a wide range of techniques and methods to improve the quality and quantity of plants. The molecular markers are the tools that have provided a new perspective for plant breeding advancements. This article has reviewed the various advantages and uses of molecular markers and the utilization of the high potential of natural polymorphisms within communities, combined wi...
متن کاملPrognostic value of simple inflammation based markers in hepatocellular carcinoma
Despite recent progression in cancer diagnosis and treatment, hepatocellular carcinoma (HCC) remains a destructive disease with a dismal prognosis. As a hallmark of cancer, tumor-associated systemic inflammation and tumor inflammatory microenvironment play significant roles in cancer development and progression. HCC represents a typical instance of inflammation-related cancer since most HCC cas...
متن کاملNew strategies in hepatocellular carcinoma: genomic prognostic markers.
Accurate prognosis prediction in oncology is critical. In patients with hepatocellular carcinoma (HCC), unlike most solid tumors, the coexistence of two life-threatening conditions, cancer and cirrhosis, makes prognostic assessments difficult. Despite the usefulness of clinical staging systems for HCC in routine clinical decision making (e.g., Barcelona-Clinic Liver Cancer algorithm), there is ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 15 شماره None
صفحات 74- 89
تاریخ انتشار 2011-07
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
کلمات کلیدی برای این مقاله ارائه نشده است
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023