Procalcitonin as a Marker of Neonatal Sepsis in Intensive Care Units
نویسندگان
چکیده مقاله:
Background: The appropriateness of using serum levels of procalcotonin (PCT) for early diagnosis of newborn sepsis is still controversial. Therefore, the objective of the present study was to compare the usefulness of PCT with those of serum levels of C-reactive protein (CRP) and white blood cell (WBC) counts in the diagnosis and response to treatment of neonatal sepsis. Methods: A total of 47 neonates (1-30 days old) were assigned to two control (n=22) and sepsis (n=25) groups. Blood samples were obtained at the outset and after 7 days of treatment for blood culture, measurement of serum levels of PCT and CRP as well as WBC counts. Data were analyzed using within and between group comparisons. Results: Serum levels of PCT were significantly higher in sepsis group (14.1±18.7 ng/ml) than that in the control group (0.38±0.43 ng/ml). In addition, after 7 days of treatment neonates who had achieved clinical recovery had a significantly lower serum PCT levels (0.26±0.37 ng/ml) than that of the same group at the beginning of the study. At a cut-off value of ≥ 0.8 ng/ml, the sensitivity, specificity, positive predictive value of, and negative predictive value of PCT were 84%, 86%, 86% and 84%, respectively. Conclusion: The findings of the present study suggest that serum levels of PCT might be a more reliable marker of infection than serum levels of CRP, or WBC counts in the early diagnosis and responses to antibiotic therapy of neonatal sepsis.
منابع مشابه
procalcitonin as a marker of neonatal sepsis in intensive care units
background: the appropriateness of using serum levels of procalcotonin (pct) for early diagnosis of newborn sepsis is still controversial. therefore, the objective of the present study was to compare the usefulness of pct with those of serum levels of c-reactive protein (crp) and white blood cell (wbc) counts in the diagnosis and response to treatment of neonatal sepsis. methods: a total of 4...
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PURPOSE We evaluated serum procalcitonin (PCT) as a diagnostic marker of neonatal sepsis, and compared PCT levels with C-reactive protein (CRP) levels. METHODS We retrospectively reviewed the medical records of 269 neonates with a suspected infection, admitted to Wonkwang University School of Medicine & Hospital between January 2011 and December 2012, for whom PCT and CRP values had been obta...
متن کاملprocalcitonin: a reliable marker for the diagnosis of neonatal sepsis
objective(s) in the last few years, serum procalcitonin has been proposed as an early marker of infections in neonates, with varying results. in this study, we aimed to investigate the value of procalcitonin, and c- reactive protein in establishing the diagnosis of neonatal sepsis. materials and methods blood samples were collected at admission from 69 neonates with suspected infection (admitte...
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متن کاملProcalcitonin: A Reliable Marker for the Diagnosis of Neonatal Sepsis
OBJECTIVES In the last few years, serum procalcitonin has been proposed as an early marker of infections in neonates, with varying results. In this study, we aimed to investigate the value of procalcitonin, and C- reactive protein in establishing the diagnosis of neonatal sepsis. MATERIALS AND METHODS Blood samples were collected at admission from 69 neonates with suspected infection (admitte...
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عنوان ژورنال
دوره 35 شماره 3
صفحات 205- 210
تاریخ انتشار 2010-09-01
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