Preparation of Chitosan Nanoparticles Loaded by Dexamethasone Sodium Phosphate

نویسندگان

  • Amir Dustgania Chemical Engineering Department, Tarbiat Modares University, Tehran, Iran
  • Ebrahim Vasheghani Farahani Chemical Engineering Department, Tarbiat Modares University, Tehran, Iran
  • Mohammad Imani Novel Drug Delivery Systems Department, Iran Polymer and Petrochemical Institute, Tehran, Iran
چکیده مقاله:

      Biodegradable nanoparticulate carriers, have important potential applications for administration of therapeutic molecules. Chitosan based nanoparticles have attracted a lot of attention upon their biological properties such as biodegradability, biocom-patibility and bioadhesivity. The aim of the present investigation was to describe the synthesis and characterization of novel biodegradable nanoparticles based on chitosan for encapsulation of dexamethasone sodium phosphate. To achieve this objective, ionic gelation method were used. Drug containing nanoparticles were prepared with different amounts of drug. The mean size and size distribution of nanoparticles were measured by dynamic laser light scattering. The mean particle size, varied in the range of 250-350 nm. Values of loading capacity and loading efficiency varied between 33.7%-72.2% and 44.5%-76.0% for prepared nanoparticles.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

preparation of chitosan nanoparticles loaded by dexamethasone sodium phosphate

biodegradable nanoparticulate carriers, have important potential applications for administration of therapeutic molecules. chitosan based nanoparticles have attracted a lot of attention upon their biological properties such as biodegradability, biocom-patibility and bioadhesivity. the aim of the present investigation was to describe the synthesis and characterization of novel biodegradable nano...

متن کامل

Preparation and Characterization of Rivastigmine Loaded Chitosan Nanoparticles

Nanotechnology mediated drug delivery has been reported to enhance the drug efficacy, bioavailability, reduce toxicity and improve patient compliance by targeting the cells and tissues to produce desired pharmacological action. Aim: The purpose of the present study was to formulate and evaluate rivastigmine loaded chitosan nanoparticles for sustained release. Methods: Rivastigmine is a short ac...

متن کامل

Preparation and Evaluation of Vancomycin-Loaded N-trimethyl Chitosan Nanoparticles

Chronic intracellular infections caused by drug-resistant pathogens pose a challenge to the treatment of chronic osteomyelitis. Such treatment requires an intracellular delivery system for the sustained release of antibiotics such as vancomycin (VCM), which is an antibiotic of last resort used against many clinically resistant bacteria. In this work, we report VCM-loaded N-trimethyl chitosan (T...

متن کامل

Preparation and Characterisation of Highly Loaded Fluorescent Chitosan Nanoparticles

Chitosan (CS) nanoparticles have been developed as a versatile drug delivery system to transport drugs, genes, proteins, and peptides into target sites. Demands on fluorescent nanoparticles have increased recently due to various applications in medical and stem-cell-based researches. In this study, fluorescent CS nanoparticles were prepared by a mild method, namely, complex coacervation. Entrap...

متن کامل

Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres

Selenium nanoparticles (SeNPs), as a special form of selenium (Se) supplement, have attracted worldwide attention due to their favorable properties and unique bioactivities. Herein, an eco-friendly and economic way to prepare stable SeNPs is introduced. SeNPs were synthesized in aqueous chitosan (CTS) and then embedded into CTS microspheres by spray-drying, forming selenium nanoparticles-loaded...

متن کامل

Exploring the Preparation of Albendazole-Loaded Chitosan-Tripolyphosphate Nanoparticles

The objective of this study was to improve the solubility of albendazole and optimize the preparation of an oral nanoparticle formulation, using β-cyclodextrin (βCD) and chitosan-tripolyphosphate (TPP) nanoparticles. The solubility of albendazole in buffers, surfactants, and various concentrations of acetic acid solution was investigated. To determine drug loading, the cytotoxic effects of the ...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 4  شماره 2

صفحات  111- 114

تاریخ انتشار 2008-04-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023