Preparation and Characterization of Estradiol Valerate Microspheres Using Biodegradable Polymers

نویسندگان

  • Fatemeh Atyabi Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  • Neda Islami Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  • Rassoul Dinarvand Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  • Shadi Moghadam Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
چکیده مقاله:

     In this study, microspheres containing estradiol valerate were prepared by solvent evaporation method using poly (glycolide-co-lactide) (PLGA 50:50) and poly (lactide). The effect of different process variables such as polymer type, drugpolymer ratio, stirring rate, volume of internal phase and temperature of external phase on the morphology, particle size distribution, encapsulation efficiency and in vitro release profile were investigated. All microspheres had spherical shape with smooth surface. Increasing the internal phase volume and decreasing the external phase temperature resulted in smaller particles. At low drug loadings, PLGA microspheres were larger than PLA ones. Changing the theoretical drug loading from 5 to 20% decreased the drug release rate from PLGA microspheres whereas the result for PLA microspheres was the opposite.

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عنوان ژورنال

دوره 2  شماره 1

صفحات  3- 10

تاریخ انتشار 2006-01-01

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