Pnm-9: Serum and Peritoneal Fluid Level of Vascular Endothelial Growth Factor in Endometriosis
نویسندگان
چکیده مقاله:
Background: Endometriosis is known as one of the most common disease in women of reproductive age. Due to importance role of vascular endothelial growth factor (VEGF) in neo-vascularization for the implantation of endometrial cell and different reported results for VEGF level in the serum and peritoneal fluid (PF) in endometriosis patients, this study was designed to determine the serum and PF levels of VEGF in endometriosis patients, and to compare it with normal subjects. Materials and Methods: Women who were subjected to laparoscopy for the evaluation of infertility or pelvic pain were allocated into two groups; women with (group I, n= 90) and without (group II, n=89) endometriosis. The PF from pelvis and venous blood samples were obtained. The VEGF concentration of the serum and PF were measured using enzyme immunoassay kit and were compared using t-Student test. Results: The level of VEGF level in serum was significantly less than in PF in both groups (p=0.00). However endometriosis patients had a higher level of VEGF in peritoneal fluid significantly when compared with nonendometriosis patients (p=0.043). Conclusion: Angiogenic activity is increased by the elevated level of VEGF in the PF of endometriosis patients. This elevated level of VEGF also promotes neovascularization within the peritoneal environment.This disease is associated with only pelvic inflammation, and is not associated change in the level of circulating VEGF.
منابع مشابه
Serum and Peritoneal Fluid Levels of Vascular Endothelial Growth Factor in Women with Endometriosis
متن کامل
serum and peritoneal fluid levels of vascular endothelial growth factor in women with endometriosis
0
متن کاملSerum and Peritoneal Fluid Levels of Vascular Endothelial Growth Factor in Women with Endometriosis
BACKGROUND Endometriosis is known as one of the most common disease in women of reproductive age. Due to important role of vascular endothelial growth factor (VEGF) in neo-vascularization for the implantation of endometrial cell, and also presence of different studies reported VEGF level in the serum and peritoneal fluid (PF) in endometriosis patients, this study was designed to determine the s...
متن کاملMethodological Concerns Regarding Levels of Vascular Endothelial Growth Factor (VEGF) in Serum of Women with Endometriosis
s:865:"We read with interest the manuscript entitled "Serum and peritoneal fluid levels of vascular endothelial growth factor in women with endometriosis" recently published in the International Journal of Fertility and Sterility (1). The authors measured the levels of vascular endothelial growth factor in serum and peritoneal fluid of 179 women, 90 of whom were diagnosed with endometriosis, an...
متن کاملVascular endothelial growth factor (VEGF) concentrations are elevated in peritoneal fluid of women with endometriosis.
Active endometriosis is characterized by hypervascularization both within and surrounding the implant; therefore the presence of angiogenic factors in the peritoneal environment would be of great importance. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor involved in both physiological and pathological angiogenesis. We sought to determine if VEGF was present in the perit...
متن کاملThe Association Analysis of Vascular Endothelial Growth Factor -2549 Insertion/Deletion Variant and Endometriosis Risk
Endometriosis is a debilitating disorder, defined as the presence of endometrial gland and stroma outside of the uterus. It may affect angiogenesis and vascular endothelial growth factor (VEGF) is one of the angiogenic factors that plays an important role in both physiological and pathological angiogenesis. The present study aimed to evaluate the association of VEGF -2549 insertion/deletion (I/...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 7 شماره 3
صفحات 133- 133
تاریخ انتشار 2013-09-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023