Pnm-24: Pharmacologic Effect of Non-Steroidal Anti-Inflammatory Drugs in Reproductive System-(An Experimental Design
نویسندگان
چکیده مقاله:
Background: Some patients that used Non-steroidal anti-inflammatory drug for a long time, as an analgesic, antipyretic or anti-inflammatory agent may be seen unusual effect of this drug on spermatogenesis and the level of blood testosterone hormone. The aim of this research is assess the effect of this drug on male-reproductive system functions Materials and Methods: This experimental research done for study of the Non-steroidal anti-inflammatory drug (celecoxib) on rat reproductive system, specially on spermatogenesis and the level of blood testosterone hormone. In this manner histologic studies and measuring of weight (testis, prostate, seminal vesicle and epidydimis) and the level of blood testestron are done. 50 rat with 200-230 gr. weight selected and compared in 5 groups. control group (no drug given), sham group (solvent drug: Di- methyl sulfoxide), 3 cases group (orally celecoxib 10, 20 and 40mg/kg given daily) for 15 days. In the end of 15 days heart blood sampling for measuring serum testestron level accomplished after that reproductive systems separated and prepared for histologic study. Results: Mean weight of body testis, epidydimis and seminal vesicle haven’t significant differences in control and case groups. But significant differences are seen in the mean weight of prostate per body weight in case group (40mg/kg) in compared with control group. That is due to ant malignant effect of celecoxib on prostate. No differences seem between control and case groups in arrangement mode, nuclei shape and cytoplasm in histological examination in spermatogonia and primary spermatocytes in transverse section of somniferous tubules celecoxib in case group (40mg/kg) can decrease lydige cells number, that is due to inhibited prostaglandin synthesize, for the result of cox-2 inhibitor and decreased level of testosterone hormone. Conclusion: In case group (40mg/kg) number of sertoli cells decreased due to decrease testestron level. It looks that number of sertoli cells in control and case groups are differences. This can cause production of abnormal sperms. We can conclude that use of high doses of celecoxib can decreased size and number of lydig cells and this is cause of decreased testosterone hormone.
منابع مشابه
P-44: Infertility and Non-Steroidal Anti- Inflammatory Drug Usage (An Experimental Design)
a:4:{s:10:"Background";s:391:"Unusual effect of celecoxib may be seen in some patients that have used this drug for a long time. Celecoxib is a form of non-steroidal anti-inflammatory drug (NSAID) that directly targets COX-2, an enzyme responsible for inflammation and pain which is the main feature of celecoxib. The goal of this survey is to assess the effect of celecoxib on male-reproductive s...
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عنوان ژورنال
دوره 5 شماره Supplement Issue
صفحات -
تاریخ انتشار 2011-09-01
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