Pharmaceutical Advances and Proteomics Researches

[Pharmaceutical basic researches aiming at clinical applications].

advances in proteomics analytical techniques

proteins are fundamental components of cells which mediate many essential biological processes. proteomics is a rapidly growing field for the study of proteome, the protein complement expressed by the genome of an organism or cell type. the large-scale analysis of proteins leads to a more comprehensive view of molecular and cellular pathways that improves the overall understanding of the comple...

Advances and Researches in Idiopathic Nephrotic Syndrome Biomarkers

In 1985, through co-culture using PBMC of patients with recurrent primary small change nephropathy (IMLNS) and normal rat glomerular, Garin found that 35sulfate absorption of glomerular was improved and proteinuria was induced. These suggested that the PBMC of patients with relapsed IMLNS may release a factor leading to this result [4] and the muddy pine can reduce 35sulfate absorption of glome...

Recent Advances on Computational Proteomics

In this work we report the recent progresses that have been achieved by our group in the last half decade on the field of computational proteomics. Specifically, we discuss the application of Molecular Dynamics Simulations and Electronic Structure Calculations in drug design, in the clarification of the structural and dynamic properties of proteins and enzymes and in the understanding of the ca...

Recent advances in plant cell wall proteomics.

The plant extracellular matrix contains typical polysaccharides such as cellulose, hemicelluloses, and pectins that interact to form dense interwoven networks. Plant cell walls play crucial roles during development and constitute the first barrier of defense against invading pathogens. Cell wall proteomics has greatly contributed to the description of the protein content of a compartment specif...