Parathyroid Carcinoma: Case Report and Review of the Literatur

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism and occurs in one percent of cases. Most of the patients at the time of diagnosis are young and the mean age is 40 year-old and occur with equal frequency in both sexes. In most series, serum calcium levels are ≽ 14 mg/dl and in half of them, a palpable cervical mass is evident. Clinical manifestations are maily due to hypercalcemia per se and include fatigue, weakness, bone pain, nephrolithiasis, polydipsia and polyuria; local and distant metastases occur only late in the course of disease. This unique case is the second one reported in Iran who came with fatigue, weakness, recurrent nephrolithiasis, right-sided mandibular tumor and a palpable neck mass. The patient underwent surgical extirpation of tumor plus ipsilateral thyroid lobectomy and discharged from the hospital in good condition. In five years follow up since the first surgery, there is no evidence of tumor recurrence and/or hypercalcemia.