P14: Mitochondria as a Target for Drug Therapy in Epilepsy
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15 صفحه اولNeurostimulation as a Putative Method for Treatment of Drug-Resistant Epilepsy in Patient and Animal Models of Epilepsy
A patient with epilepsy was shown to have neurobiological, psychological, cognitive, and social issues as a result of recurring seizures, which is regarded to be a chronic brain disease.However, despite numerous drug treatments, approximately, 30–40% of all patients are resistant to antiepileptic drugs. Therefore, newer therapeutic modalities are introduced into clinical practice in which invol...
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Lamotrigine (LTG), a newly developed antiepileptic drug (AED), is efficacious in treating refractory epilepsy. This study was designed to evaluate the efficacy and safety of LTG as add-on therapy in 40 children with refractory epilepsy. The trial was an open-labeled prospective study in children with drug-resistant epilepsy aged
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Mitochondria are organelle, which is found in most eukaryotic cells, and play an im‐ portant roll in production of many biosynthetic intermediates as well as energy trans‐ duction. Recently, it has been reported that mitochondria contribute to cellular stress responses such as apoptosis and autophagy. These functions of mitochondria are known to be essential for survival and maintenance of home...
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Epileptic seizures occur as a result of episodic abnormal synchronous discharges in cerebral neuronal networks. Although a variety of non-conventional mechanisms may play a role in epileptic synchronization, cascading excitation within networks of synaptically connected excitatory glutamatergic neurons is a classical mechanism. As is the case throughout the central nervous system, fast synaptic...
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Endocannabinoid (ECB) system plays a vital role in responses to stress. Moreover, ECB and its receptors cause anti-inflammatory, anti-oxidative and neuroprotective effects by modulating neuronal, glial and endothelial cell functions. A number of studies have demonstrated ECB system notably defects in neurotraumatic and neurodegenerative diseases like epilepsy, TBI, Alzheimer’s disease and...
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عنوان ژورنال
دوره 6 شماره 3
صفحات 41- 41
تاریخ انتشار 2018-07
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