P-85: Effect of Metformin on Anti-Mullerian Hormone (AMH) Level in Women with Infertility and Polycystic Ovary Syndrome

Background Women with PCOS have increased AMH levels due to accumulated preantral and small antral in follicles. Ovulation improvement following decrease in levels of AMH could accure in these patients. The purpose of this study was to evaluate the effect of metformin on anti-Mullerian hormone levels in women with polycystic ovary syndrome and infertility MaterialsAndMethods This randomized clinical trial study was done on 30 infertile patients with polycystic ovary syndrome (using the Rotterdam criteria) in 1393, in infertility center of Shahid Beheshti hospital in kashan. Demographic data included age, BMI, history of abortion and contraception, and hirsutism were recorded. Metformin 1, 500 mg for 8 weeks were prescribed, then AMH level was checked before and after treatment. Results were analyzed by using X2, t test, Mann-Whitney and logistic regression. Results Mean age of patients was 25.2 ± 4.2 years and BMI was 26.2 ± 3.8. Patients had 60% hirsutism, 93% oligomenorrhea and 80% infertility. AMH levels before treatment with metformin was equal to 10 ± 3.75 and after treatment was 7.8 ± 3.7 which decreased significantly (P=0.008). Conclusion The results of this study showed that metformin for 2 months could decrease AMH significantly.