P-65: Efficacy of Chamomile- Extract on PolycysticOvary Syndrome in Rat

Background: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction. Presently, little is known about the primary factors that initiate the PCOS dysfunction. Chamomile flowers are used in alternative medicine for its anti-spasmolytic and inflammatory effects. Antispasmodic properties of chamomile ease menstrual cramps and lessen the possibility of premature labor. This medicinal herb also stimulates menstruation. In this study, we evaluated the effects of Chamomile alcoholicextract on the biochemical and clinical parameters in a rat model of PCOS. Materials and Methods: Estrous cyclicity of 30 virgin adult cycling rats was monitored by vaginal smears obtained between 0800 and 1200 hours. After about 4 days each received an i.m. injection of Estradiol Valerate (Aburaihan Co., Iran), 2mg in 0.2 ml of corn oil, to induce PCO. Control rats were injected with corn oil. All the rats in the experimental group were evaluated for follicular cysts 60 days after the injection. Later, the rats with PCOS were treated by multiple doses (25, 50, 75 mg/kg) of intraperitoneal injections of Chamomile alcoholic-extract for ten days. SPSS 13 was used for statistical data analysis and data, were analyzed by ANOVA, followed by the Student- Newman- Keuls Post hoc test p