P-54: Metabolic Abnormalities in Adolescents with Polycystic Ovary Syndrome in Zanjan-Iran

Background: Adults with polycystic ovary syndrome (PCOS) can have multiple metabolic abnormalities. However, studies in the adolescent population are still limited and these results seem to vary widely. This study was to investigate the metabolic abnormalities in adolescents with PCOS in Zanjan-Iran and potential risk factors contributed to these health risks. Materials and Methods: Anthropometric measurements and biochemical parameters were evaluated in 30 adolescents with PCOS and their age matched controls. Results: The prevalence of metabolic syndrome in adolescents with PCOS was more than normal adolescents (30% vs. 12.7%, p=0.038) and adolescents with PCOS had higher BMI and HOMA-IR (p < or = 0.005). Conclusion: Adolescents with PCOS in Zanjan had more metabolic abnormalities than their age-matched non-PCOS counterparts. Obesity could worsen insulin resistance, hyperinsulinemia and metabolic syndrome in PCOS adolescents.