P-41: Evaluation of CAPZA3 Expression in Infertile Individuals Undergoing Intracytoplasmic Sperm Injection

نویسندگان

  • Ghaedi K
  • Javadi GR
  • Tanhaee S
  • Tavalaee M
چکیده مقاله:

Background: CAPZA3 is one of the actin-capping proteins believed to be play an important role in controlling of actin polymerization during spermiogenesis and has been shown to be peresent in mature sperm. Immunohistochemistry showed that human CAPZA3 is localized in the neck region of ejaculated sperm, with moderate and faint signals also detected in the tail and post-acrosome region respectively. For the first time, we evaluated correlation between CAPZA3 expression and fertilization rate in infertile men undergoing ICSI (intracytoplasmic sperm injection). Materials and Methods: We have measured the expression of CAPZA3 in 25 infertile men candidate ICSI with realtime PCR technique. Results: We observed a significant correlation between CAPZA3 expression and fertilization rate in these infertile men. Conclusion: CAPZA3 may play a physiologically role in sperm construction and fertility in human.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Acupuncture Treatment For Infertile Women Undergoing Intracytoplasmic Sperm injection

Background Little information exists regarding the use of acupuncture in combination with allopathic treatment of infertility. Objective To describe the use of acupuncture to stimulate follicle development in women undergoing in vitro fertilization. Design, Setting, and Patients Prospective case series of 6 women receiving intracytoplasmic sperm injection and acupuncture along with agents for o...

متن کامل

Sex chromosome mosaicism in couples undergoing intracytoplasmic sperm injection.

BACKGROUND Several studies have shown an increased frequency of constitutional chromosome aberrations in male and female partners of couples examined prior to ICSI. We conducted a cohort study to determine whether there was an increase in numerical sex chromosome mosaicism among couples undergoing ICSI compared with fertile couples. METHODS Cytogenetic investigations were performed in 228 fem...

متن کامل

Intracytoplasmic Sperm Injection

Intracytoplasmic Sperm Injection (ICSI) is an assisted reproductive technique [4] (ART) initially developed by Dr. Gianpiero D. Palermo [5] in 1993 to treat male infertility [6]. It is most commonly used in conjunction with in vitro [7] fertilization [8] (IVF) or a less commonly used technique called zygote intrafallopian transfer [9] (ZIFT). In natural fertilization [8], the sperm [10] must pe...

متن کامل

Intracytoplasmic sperm injection (ICSI)

IVF has become a well-established treatment for certain types of infertility, including long-standing infertility due to tubal disease, endometriosis, unexplained infertility or infertility involving a male factor. Soon it became clear that certain couples with severe male-factor infertility could not be helped by conventional IVF. Extremely low sperm counts, impaired motility and/or abnormal m...

متن کامل

Long‐term clinical outcomes of testicular sperm extraction and intracytoplasmic sperm injection for infertile men

Purpose To find the best methods to achieve the highest pregnancy and birth rates for couples needing testicular sperm extraction (TESE)-intracytoplasmic sperm injection (ICSI). Methods Retrospectively studied were 801 patients with male factor infertility who had undergone TESE-ICSI between April, 1996 and July, 2016 and who had been categorized into four groups: obstructive azoospermia (OA)...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 6  شماره 2

صفحات  -

تاریخ انتشار 2012-09-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023